Skip to main content
SpringerLink
Log in

Modulation of the Responsiveness of Cerebellar Purkinje Cells to Excitatory Amino Acids

  • Chapter
Excitatory Amino Acids and Neuronal Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 268))

Abstract

Since the discovery and classification of receptor-types to excitatory amino acids (EAAs), (36) numerous studies have analyzed their role in synaptic plasticity, showing that, in particular in the hippocampus, n-methyl-D-aspartate (NMDA) receptors play a crucial role in long term potentiation of synaptic transmission (ref. dans 5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albus, J.S. (1971): A theory of cerebellar function. Math. Biosci. 10: 25–61

    Article  Google Scholar 

  2. Alkon, D.L. and Rasmussen, H. (1988): A spatial-temporal model of cell activation. Science 239, 988–1005.

    Article  Google Scholar 

  3. Altman, J. (1972): Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J.Comp.Neurol. 145: 399–464

    Article  PubMed  CAS  Google Scholar 

  4. Ascher, P. and Nowak, L. (1986): Calcium permeability of the channels activated by N-Methyl-D-aspartate (NMDA) in isolated mouse central neurones. J.Physiol. ( London ) 377: 43P

    Google Scholar 

  5. Bliss, T.V.P. and Lynch, M.A. (1988): Long term potentiation of synaptic transmission in hippocampus: Properties and mechanisms. In long term potentiation from biophysics to behavior 3–72 Alan R. Liss. Inc.

    Google Scholar 

  6. Brindley, G.S. (1964): The use made by the cerebellum of the information that it receives from sense organs. I.B.R.O. Bull. 3–80

    Google Scholar 

  7. Castagna, M.,Takai, Y.,Kaibuchi, K.,Sano, K.,Kikkawa, U. and Nishizuka,Y. (1982): Direct activation of calcium-activated,phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J.Biol Chem. 257: 7847–7851

    Google Scholar 

  8. Crepel, F.,Dhanjal, SS. and Sears, T.A. (1982): Effect of glutamate, aspartate and related derivatives on cerebellar Purkinje cell dendrites in the rat: An in vitro study. J. Physiol. ( London ) 329: 297–317

    Google Scholar 

  9. Crepel, F., Dupont, J.L. and Gardette, R. (1982): Connectivity and chemosensitivity of Purkinje cells in the immature cerebellum: an in vitro study. J. Physiol.(London) 332: 62 P

    Google Scholar 

  10. Crepel, F.,Dupont, J.L. and Gardette, R. (1983): Voltage-clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro. Brain Research 279: 311–315

    Article  Google Scholar 

  11. Crepel, F. and Krupa, M. (1988): Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study. Brain Res. 458: 397–401

    Article  PubMed  CAS  Google Scholar 

  12. Downing, J.E.G. and Role, L. (1987): Activators of protein kinase C enhance acetylcholine receptor desensitization in synpathic ganglion neurons. Proc. Natl. Acad. Sci. USA. 84: 7739–7743

    Article  PubMed  CAS  Google Scholar 

  13. Dupont, J.L.,Gardette, R and Crepel, F. (1987): Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids. An in vitro study. Developmental Brain Research 34: 59–68

    Article  CAS  Google Scholar 

  14. Eccles, J.C., Ito, M. and Szentagothai, J. (1967): The cerebellum as a neuronal machine. Springer-Verlag. New-York. Heidelberg.

    Google Scholar 

  15. Eccles, J.C.,Llinas, R. and Sasaki, K. (1966): The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J. Physiol. ( London ) 182: 268–296

    CAS  Google Scholar 

  16. Exton, J.H. (1985): Mechanisms involved in alpha-adrenergic phenomena. Am. J. Physiol. 248: E633 - E647

    PubMed  CAS  Google Scholar 

  17. Gonzales, R.A.,Greger, Jr, P.H.,Baker, S.P.,Ganz, N.I.,Bolden, C.,Raizada, M.K. and Crews, F.T. (1987): Phorbol esters inhibit agonist-stimulated phosphoinositide hydrolysis in neuronal primary cultures. Develop.Brain Research 37: 59–66

    Article  Google Scholar 

  18. Ito, M. (1987): Characterization of synaptic plasticity in the cerebellar and cerebral neocortex. In Changeux, J.P. and Nonishi, M. Eds. The Neural and Molecular bases of Learning, John Wiley and Sons, LTD, 276–279

    Google Scholar 

  19. Ito, M. (1989): Long term depression. Ann. Rev. Neurosci. 12: 85–102

    Article  PubMed  CAS  Google Scholar 

  20. Ito, M., Sakurai, M. and Tongreach, P. (1982): Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J. Physiol. ( London ) 324: 113–134

    CAS  Google Scholar 

  21. Kano, M. and Kato, M. (1987): Quiqualate receptors are specifically involved in cerebellar synaptic plasticity. Nature 325: 276–279

    Article  PubMed  CAS  Google Scholar 

  22. Kano, M. and Kato, M. (1989): Mode of induction of long term depression at parallel fibre-Purkinje cell synapses in rabbit cerebellar cortex. Neurosci. Res. 5: 544–556

    Article  Google Scholar 

  23. Llinas, R. and Sugimori, M. (1980): Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J. Physiol. ( London ) 305: 171–195

    CAS  Google Scholar 

  24. Lllnas, R. and Sugimori, M. (1980): Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J. Physiol. ( London ) 305: 197–213

    Google Scholar 

  25. Lohmann, S.M., Walker, U., Miller, P. E., Greengard, P., Camilli, P. D. (1981): Inununohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. Proc. Natl. Acad. Sci. USA. 78: 653–657

    Article  PubMed  CAS  Google Scholar 

  26. MacDermott, A.B., Mayer, M.L., Westbrook, G.L., Smith, S.J. and Barker, J.L. (1986): NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321: 519–522

    Article  PubMed  CAS  Google Scholar 

  27. Marr, D. (1969): A theory of cerebellar cortex. J. Physiol. (Lond.) 202: 437–470

    CAS  Google Scholar 

  28. MC Bride, W.J., Nadi, N.S., Altman, J. and Apprison, M.H. (1976): Effects of selective doses of X-irradiation on the levels of several amino acids in the cerebellum of the rat. Neurochem. Res. 1: 141–152

    Article  Google Scholar 

  29. Nicoletti, F., Iadarola, M.J., Wroblews, J.T., and Costa, E.: (1986) Excitatory amino-acid recognition sites coupled with inositol phospholipid-metabolism. Developmental changes and interaction with alpha-1 adrenoceptors. Proc. Nat. Acad. Sci. USA. 83: 1931–1935

    Article  PubMed  CAS  Google Scholar 

  30. Nishizuka, Y. (1986): Studies and perspectives in protein kinase C. Science 233: 305–312

    Article  PubMed  CAS  Google Scholar 

  31. Recasens, M., Sassetti, I., Nourigat, A., Sladecze, F., and Bockaert, J. (1987): Characterization of subtypes of excitatory amino-acid receptors involved in the stimulation of inositol phosphate synthesis in rat-brain synaptoneurosomes. Eur. J. Pharmacol. 141: 87–93

    Article  PubMed  CAS  Google Scholar 

  32. Ross, W. and Werman, R. (1987): Mapping calcium transiants in the dendrites of Purkinje cells from the guinea-pig cerebellum in vitro. J. Physiol. ( London ) 389: 319–336

    CAS  Google Scholar 

  33. Sakurai, M. (1987): Synaptic modification of parallel fibre-Purkinje cell transmission in in vitro guinea-pig cerebellar slices. J. Physiol. ( London ) 394: 463–480

    CAS  Google Scholar 

  34. Sakurai, M. (1988): Depresion and potentiation of parallel fiber-Purkinje cell transmission in in vitro cerebellar slices. In Olivo cerebellar system in motor control, Ed. P. Strata, Berlin Springer-Verlag, in Press

    Google Scholar 

  35. Sladeczek, F., Pin, J.P., Recasens, M., Bockaert, J. and Weiss, S.: (1985) Glutamate stimulates inositol phosphate formation in striatal neurones. Nature 314: 717–719

    Article  Google Scholar 

  36. Watkins, J.C. (1981): Pharmacology of excitatory amino acid transmitters. In F.V. De Feudis and P. Mandel, Eds. Advances in Biochemical Psychopharmacology, Vol. 29, Amino acid neurotransmitters, Raven, New-York, 205–212

    Google Scholar 

  37. Wiklúnd, G., Toggenburger, G., Cuenod, M. (1982): Aspartate: possible neurotransmitter in cerebellar climbing fibers. Science, 216: 78–79

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Neurobiologie du Développement. URA CNRS 1121, Université Paris-Sud, 91405, Orsay Cedex, France

    Francis Crépel & Mireille Krupa

Authors
  1. Francis Crépel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mireille Krupa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut National de la Sante et de la Recherche Medicale, Paris, France

    Yehezkel Ben-Ari

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media New York

About this chapter

Cite this chapter

Crépel, F., Krupa, M. (1990). Modulation of the Responsiveness of Cerebellar Purkinje Cells to Excitatory Amino Acids. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_36

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5769-8_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5771-1

  • Online ISBN: 978-1-4684-5769-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation