Abstract
1. Mode of action:
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a)
Antihistamines block the effects of histamine on smooth muscle (blood vessels, gut, bronchi). The stimulant effect of histamine on gastric secretion is not blocked by antihistamines.
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b)
Antihistamines inhibit the effects of histamine which is released by liberating substances (compound 48/80, morphine, D-tubocurarine and others), which act by releasing histamine from mast cell granules. Non mast-cell histamine is not released by these liberators.
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c)
Antihistamines inhibit the development of anaphylactic shock, which is caused by release of histamine by antigen-antibody reactions. Exception: The histamine release caused by antigen-antibody reactions of fixed antibodies is influenced to a lesser degree.
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© 1969 Springer-Verlag Berlin · Heidelberg
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Lembeck, F., Sewing, KF. (1969). Antihistamines. In: Pharmacological facts and figures. Heidelberg Science Library. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-6243-2_6
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DOI: https://doi.org/10.1007/978-1-4684-6243-2_6
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