Abstract
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and Calne, 1979). Binding of dopamine to its receptors induces several second messenger systems, most importantly affecting cAMP levels (Vallar and Meldolesi, 1989). Activation of the D1 receptor stimulates adenylyl cyclase activity which results in an increase in intracellular cAMP levels while binding of dopamine to the D2 receptor inhibits the cyclase activity (Caron et al., 1978).
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© 1992 Birkhäuser Boston
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Civelli, O., Bunzow, J., Albert, P., Van Tol, H.H.M., Grandy, D. (1992). The Dopamine D2 Receptor. In: Brann, M.R. (eds) Molecular Biology of G-Protein-Coupled Receptors. Applications of Molecular Genetics to Pharmacology. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6772-7_7
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DOI: https://doi.org/10.1007/978-1-4684-6772-7_7
Publisher Name: Birkhäuser Boston
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