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Apoptosis and Cytotoxic T Lymphocytes

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Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

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Abstract

Apoptosis is a mode of cell death that occurs under normal physiological conditions. In vivo, it is most often found during normal tissue turnover, embryogenesis, metamorphosis, and endocrine-dependent tissue atrophy (Kerr et al., 1972; Wyllie et al., 1980). The inference has been made that cell death in these instances is “programmed,” meaning that it is a normal function of the cell, tissue, or organ. This has led some investigators to use the terms apoptosis and programmed cell death (PCD) interchangeably, although it is becoming apparent that there are examples of PCD which are not apoptotic and examples of apoptosis which are not truly programmed (Cohen, 1991; Cohen et al., 1992). Nevertheless, the fact that the morphological and biochemical changes associated with apoptosis are highly conserved in various cell types and systems suggests that an apoptotic mechanism (cell death program) exists in all cells that can be activated under the appropriate physiological conditions.

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  1. Richard C. Duke
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Editors and Affiliations

  1. Laboratory of Immunology, Biochemistry and Immunopharmacology Unit, NIH-NIAID, 20892, Bethesda, Maryland, USA

    Michail V. Sitkovsky

  2. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Pierre A. Henkart

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© 1993 Birkhäuser Boston

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Duke, R.C. (1993). Apoptosis and Cytotoxic T Lymphocytes. In: Sitkovsky, M.V., Henkart, P.A. (eds) Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6814-4_20

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  • DOI: https://doi.org/10.1007/978-1-4684-6814-4_20

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6816-8

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