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Interactions of Estrogenic Pesticides with Cytochrome P450

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Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds

Part of the book series: NATO ASI Series Advanced Science Institutes Series ((NSSA,volume 202))

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Abstract

This presentation examines a variety of questions concerning the interactions of chlorinated hydrocarbon pesticides with cytochrome P450 monooxygenases. In particular, it intends to discuss those pesticides which exhibit estrogenic activity in mammals. An important question concerns whether the estrogenic activity of these pesticides resides in the parent compound or whether estrogenicity of these compounds is primarily due to their respective metabolites. In the latter case, it is anticipated that the alteration in the activity of the enzymes catalyzing the formation of these metabolites would have a pronounced effect on the estrogenic activity of the parent compound. Hence it would be important to identify the enzymes (P450s) catalyzing their formation. These aspects will be examined in some detail.

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Author information

Authors and Affiliations

  1. Worcester Foundation for Experimental Biology, 222 Maple Avenue, Shrewsbury, MA, 01545, USA

    David Kupfer

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  1. David Kupfer
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Editor information

Editors and Affiliations

  1. Middle East Technical University, Ankara, Turkey

    Emel Arinç

  2. University of Connecticut Health Center, Farmington, Connecticut, USA

    John B. Schenkman

  3. North Carolina State University, Raleigh, North Carolina, USA

    Ernest Hodgson

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© 1991 Plenum Press, New York

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Kupfer, D. (1991). Interactions of Estrogenic Pesticides with Cytochrome P450. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. NATO ASI Series Advanced Science Institutes Series, vol 202. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7284-4_19

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  • DOI: https://doi.org/10.1007/978-1-4684-7284-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7286-8

  • Online ISBN: 978-1-4684-7284-4

  • eBook Packages: Springer Book Archive

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