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Molecular and Cellular Mechanisms of Multistage Carcinogenesis; Role of Oncogenes and Intercellular Communication

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Skin Pharmacology and Toxicology

Part of the book series: NATO ASI Series ((NSSA,volume 181))

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Abstract

It is now widely accepted that the process by which a normal cell becomes malignant is multistage (1–3). This notion is supported from various aspects, including molecular biology studies and epidemiological analysis of human cancer (1–5). The latest evidence for the multistage nature of the carcinogenesis process has come from the use of transgenic mice which contain various introduced oncogenes (6,7). For example, in transgenic mice which harbour a c-myc gene linked to murine mammary tumour virus promoter, mammary gland tumours are observed. However, these tumours are discrete; in other words, not all cells participate to form tumours in spite of the fact that each cell harbours the activated myc gene (8). Similar results were obtained with transgenic mice which contained various other introduced oncogenes (for review, 6,7). Thus it is apparent that oncogene expression in transgenic mice is important but not sufficient to produce tumours, supporting the concept of multistage carcinogenesis. An apparent exception has recently been reported: transgenic mice containing the neu oncogene developed mammary gland tumours in which all cells participated (9). This particular study suggests a single step carcinogenesis as claimed by the authors (9) but further analysis is necessary to determine whether or not other events are involved in the genesis of tumours in these transgenic mice.

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  1. International Agency for Research on Cancer, Lyon, France

    Hiroshi Yamasaki

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  1. Hiroshi Yamasaki
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  1. University of Milan, Milan, Italy

    Corrado L. Galli  & Marina Marinovich  & 

  2. Centre International de Recherche Dermatologique (C.I.R.D.), Valbonne, France

    Christopher N. Hensby

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Yamasaki, H. (1990). Molecular and Cellular Mechanisms of Multistage Carcinogenesis; Role of Oncogenes and Intercellular Communication. In: Galli, C.L., Hensby, C.N., Marinovich, M. (eds) Skin Pharmacology and Toxicology. NATO ASI Series, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7902-7_14

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