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The Value of Biokinetic Data in Hazard and Risk Assessment

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New Trends in Pharmacokinetics

Part of the book series: NATO ASI Series ((NSSA,volume 221))

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Abstract

Paracelsus, 16th century Swiss physician and recognized father of Toxicology, is quoted as stating [Klaassen and Doull, 1980] “All substances are poisons; there is none which is not a poison. The right dose differentiates between a poison and a remedy”. Therefore, a functional definition for toxicity would state that virtually every substance possesses the potential to produce injury or death (hazard) if available in a sufficient amount (exposure). This idea encompasses not only the response to the substance but also the delivery of the dose to the target tissue(s), and hence implies hazard and exposure or risk. In the biological model, risk is determined by a dynamic sequence of events; biokinetics, whether restricted to a pharmacological response or an overdose expressing itself as a toxicological response, is central to understanding risk.

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Authors and Affiliations

  1. CIBA-GEIGY Corporation, Greensboro, N.C., 27419, USA

    James T. Stevens & Darrell D. Sumner

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  1. James T. Stevens
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  2. Darrell D. Sumner
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Editors and Affiliations

  1. University of Parma, Parma, Italy

    Aldo Rescigno

  2. Hazleton Washington, Inc., Vienna, Virginia, USA

    Ajit K. Thakur

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© 1991 Plenum Press, New York

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Stevens, J.T., Sumner, D.D. (1991). The Value of Biokinetic Data in Hazard and Risk Assessment. In: Rescigno, A., Thakur, A.K. (eds) New Trends in Pharmacokinetics. NATO ASI Series, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8053-5_18

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  • DOI: https://doi.org/10.1007/978-1-4684-8053-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8055-9

  • Online ISBN: 978-1-4684-8053-5

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