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Apoptosis and Cancer

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Basic Science of Cancer

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Abstract

Apoptosis, or Programmed Cell Death, is the activation of an inherent cellular suicide program that results in cell death [1]. There are two hallmarks in the death process. First, is a set of distinct morphologic changes such as membrane blebbing, cell shrinkage, and chromosomal condensation followed by chromosomal fragmentation. Second, is the rapid phagocytosis of the corpses of the dead cells, resulting in a limited local immune response. Recently it has been demonstrated that apoptosis plays a crucial role in cardiac damage and a variety of human diseases such as acute liver failure, Alzheimer’s disease, and cancer [2]. The realization that apoptosis constitutes a major mechanism of tumor suppression has dramatically advanced tumor biology by leading to a number of novel approaches for preventing, diagnosing, and treating cancer. The guiding principles for understanding and manipulating the apoptotic response have emerged from studies of both lower eukaryotes and mammalian model systems [3]. These principles, as well as strategies designed to harness the apoptotic response, are described in this chapter.

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Authors
  1. Fruma Yehiely
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  2. Louis P. Deiss
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Editors and Affiliations

  1. Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA, USA

    Gary D. Kruh MD, PhD (Member) (Member)

  2. Department of Pharmacology, G. Willing Pepper Chair in Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA

    Kenneth D. Tew PhD, DSc (Chairman) (Chairman)

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Yehiely, F., Deiss, L.P. (2000). Apoptosis and Cancer. In: Kruh, G.D., Tew, K.D. (eds) Basic Science of Cancer. Current Medicine Group. https://doi.org/10.1007/978-1-4684-8437-3_11

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  • DOI: https://doi.org/10.1007/978-1-4684-8437-3_11

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