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Control of Sterol Biosynthesis and its Importance to Developmental Regulation and Evolution

  • Chapter
Biochemistry of the Mevalonic Acid Pathway to Terpenoids

Part of the book series: Recent Advances in Phytochemistry ((RAPT,volume 24))

Abstract

Sterols are virtually ubiquitous constituents of all living systems at some point in their life history.1,2 In a few organisms they are replaced by pentacyclic triterpenoids.3–5 Although sterols may differ structurally from each other they share similar amphiphathic properties which make them suitable as membrane components. The principal function for sterols and sterol-like molecules is thought to be a non-metabolic one as an architectural component of membranes; while at the same time at sites not yet clear, there appears to be additional developmentally regulated functions for sterols to control the cell cycle.6–10 The multiple sterol functions appear to be species specific, but which sterol is essential in sterol-controlled ontogenetic events6 is not always predictable with the current data base. This chapter will be concerned with approaches developed in this laboratory to interrupt sterol biosynthesis and to assess the functional importance of sterols in the regulation of growth and reproduction of plants and fungi.

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  1. Plant and Fungal Lipid Research, Plant Physiology Research Unit, Russell Research Center, 950 College Station Rd., Athens, GA, 30613, USA

    W. David Nes

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  1. University of British Columbia, Vancouver, British Columbia, Canada

    G. H. Neil Towers

  2. Reed College, Portland, Oregon, USA

    Helen A. Stafford

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Nes, W.D. (1990). Control of Sterol Biosynthesis and its Importance to Developmental Regulation and Evolution. In: Towers, G.H.N., Stafford, H.A. (eds) Biochemistry of the Mevalonic Acid Pathway to Terpenoids. Recent Advances in Phytochemistry, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8789-3_9

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