Skip to main content

Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition

  • Chapter
In Vivo Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 149))

Abstract

We have examined the organ specificity of migration of three major subpopulations of mature small lymphocytes in the mouse — B cells, the Ly-2- and Lyt-2+ T cells. It is shown that difference in the distribution of these lymphocyte classes between Peyer’s patches (PP’s) and peripheral lymph nodes (PN’s) are determined by selective recognition of endothelial determinants associated with high endothelial venules (HEV) in these organs. HEV are specialized venules that mediate lymphocyte exit from the blood into lymph nodes and Peyer’s patches. In addition, we report preliminary studies of the HEV-recognition specificity of gut-derived (mesenteric node) immunoblasts.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. E.C. Butcher, and I.L. Weissman. J. Immunol. Methods 37:97 (1980).

    Article  PubMed  CAS  Google Scholar 

  2. E.C. Butcher, R.G. Scollay, and I.L. Weissman. J. Immunol. Methods 37:109 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. E.C. Butcher, R.G. Scollay, and I.L. Weissman. Eur. J. Immunol. 10:556 (1980).

    Article  PubMed  CAS  Google Scholar 

  4. H.B. Stamper, Jr., and J.J. Woodruff. J. Exp. Med. 144:838 (1976).

    Article  Google Scholar 

  5. E.C. Butcher, R.G. Scollay, and I.L. Weissman. J. Immunol. 123:1996 (1979).

    Google Scholar 

  6. M.E. Smith, A.F. Martin, and W.L. Ford. Monogr. Allery 16:203 (1979).

    Google Scholar 

  7. E.C. Butcher, and I.L. Weissman, in: “Blood Cells and Vessel Walls: Functional Interactions”, Ciba Foundation Symposium 71, Excerpta Medica, Amsterdam (1979).

    Google Scholar 

  8. E.C. Butcher, S.K. Stevens, R.A. Reichert, and I.L. Weissman, in: “Recent Advances in Mucosal Immunity”, K. Sell, ed. Raven Press, New York (1981) in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Butcher, E.C., Kraal, G., Stevens, S.K., Weissman, I.L. (1982). Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-9066-4_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9068-8

  • Online ISBN: 978-1-4684-9066-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics