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Quantum-Mechanical Approaches to the Study of Enzymic Transition States and Reaction Paths

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Transition States of Biochemical Processes

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Abstract

Over the last 30 years, transition-state theory has provided a suitable theoretical framework for interpreting a wide range of chemical(1) and biological(2) processes. Nevertheless, it is only within the last few years, due in large measure to the approximately parallel and related development of high-speed digital computers and practical quantum-mechanical procedures for studying the geometric and electronic structure of molecules, that the full potential of transition-state theory is beginning to be realized.

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Authors and Affiliations

  1. Departments of Biochemistry and Chemistry, University of Kansas, Lawrence, Kansas, USA

    Gerald M. Maggiora & Ralph E. Christoffersen

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  1. Gerald M. Maggiora
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  2. Ralph E. Christoffersen
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Editors and Affiliations

  1. Department of Chemistry, Louisiana State University, 70803, Baton Rouge, Louisiana, USA

    Richard D. Gandour

  2. Department of Chemistry, University of Kansas, 66045, Lawrence, Kansas, USA

    Richard L. Schowen

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Maggiora, G.M., Christoffersen, R.E. (1978). Quantum-Mechanical Approaches to the Study of Enzymic Transition States and Reaction Paths. In: Gandour, R.D., Schowen, R.L. (eds) Transition States of Biochemical Processes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9978-0_3

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  • DOI: https://doi.org/10.1007/978-1-4684-9978-0_3

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