Skip to main content
SpringerLink
Log in

Protective Role of Fiber in Carcinogenesis

  • Chapter
Nutritional Biochemistry and Pathology

Part of the book series: Nutrition and Food Science ((NFS,volume 3))

Abstract

The notion that specific food components may be implicated in cancer etiology has first been raised at least in the beginning of the century1. By 1940 there were already hundreds of laboratory experiments supporting this concept, usually referring to such substances as fats, carbohydrates or total caloric intake. All along, fiber has been left in a dormant stage, being considered as an inert substance, with no after-affects following its travel along the gastro-intestinal tract.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Russel, F.A.R. “Notes on the causation of cancer”. Longmans, Green and Co. London, New York, Bombay, Calcutta, Madras, 1916.

    Google Scholar 

  2. Burkitt, D.P. Epidemiology of cancer of the colon and rectum. Cancer, 28:3–13, 1971.

    Article  CAS  Google Scholar 

  3. Malthortra, S.L. Geographical distribution of gastro-intestinal cancers in India with special reference to causation. Gut 8: 361–371, 1967.

    Article  Google Scholar 

  4. Oettle, G.G. Cancer in Africa, especially in region south of the Sahara. J. Natl. Cancer Inst. 33: 385–439, 1964.

    Google Scholar 

  5. Cleave, T.L. Diseases of Western civilization. Br. Med. J. 1: 678–679, 1973.

    Google Scholar 

  6. Walker, A.R.P. and Arvidsson, U.B. Fat intake, serum cholesterol concentration and atherosclerosis in the South African Bantu. J. Clin. Invest. 33: 1358–1365, 1954.

    Article  CAS  Google Scholar 

  7. Rusch, H.P. Extrinsic factors that influence carcinogenesis. Physiol. Rev. 24: 177–204, 1944.

    CAS  Google Scholar 

  8. Kinosita, R. Gann 33: 225, 1939.

    Google Scholar 

  9. Ando, T. Gann 33: 371, 1940.

    Google Scholar 

  10. Fischer-Wasels, B. Zentralb f allg Path. u Path. Anat. 66: 359, 1936.

    Google Scholar 

  11. Harvey, R.F., Pomare, E.W. and Heaton, K.W. Effects of increased dietary fibre on intestinal transit. Lancet, 1278–1280, 1973.

    Google Scholar 

  12. Payler, D.K., Pomare, E.W, Heaton, K.W. and Harvey, R.F. The effect wheat bran on intestinal transit. Gut 16: 209–213, 1975.

    Article  CAS  Google Scholar 

  13. Walker, A.R.P. Diet, bowel, motility, faeces composition and colonic cancer. S. Afr. Med. J. 45: 377–379, 1971.

    CAS  Google Scholar 

  14. Dwyer, J.T., Goldin, B., Gorbach, S. and Patterson, J. Drug therapy reviews: Dietary fiber and fiber supplements in the therapy of gastrointestinal disorders. Am. J. Hosp. Pharm. 35: 278–287, 1978.

    CAS  Google Scholar 

  15. Walker, A.R.P. and Burkitt, D.P. Colon cancer: Epidemiology. Seminars in Oncol 3: 341–350, 1976.

    CAS  Google Scholar 

  16. Mathe, D., Lutton, C., Rautureau, J., Coste, T., Gouffier, E., Sulpice, J.C. and Chevallier, F. Effects of dietary fiber and salt mixtures of the cholesterol metabolism of rats. J. Nutr. 107: 466–474, 1977.

    CAS  Google Scholar 

  17. Burkitt, D.P. Large-bowel cancer: An epidemiologic jigsaw puzzle. J. Natl. Cancer Inst. 54: 3–6, 1975.

    CAS  Google Scholar 

  18. Renwick, A.G. and Drasar, B.S. Environmental carcinogens and large bowel cancer. Nature 263: 234–235, 1976

    Article  CAS  Google Scholar 

  19. Hill, M.J. and Wynder, E.L. The etiology of colon cancer. CRC Critical Reviews in Toxicology. 31–82, 1975.

    Google Scholar 

  20. Walker, A.R.P. Colon cancer and diet, with special reference to intakes of fat and fiber. Amer. J. Clin. Nutr. 29: 1417–1426, 1976.

    CAS  Google Scholar 

  21. Irving, D. and Drasar, B.S. Fibre and cancer of the colon. Br. J. Cancer 28: 462, 1973.

    Article  CAS  Google Scholar 

  22. McLellan, R. Dietary fibre, transit time, faecal bacteria, steroids and colon cancer in two Scandinavian populations. Lancet: 207–211, 1977.

    Google Scholar 

  23. Hill, M.J., Crowther, J.S., Drasar, B.S., Hawksworth, G., Aries, V. and Williams, R.E.O. Bacteria and aetiology of cancer of large bowel. Lancet: 96–99, 1971.

    Google Scholar 

  24. Modan, B., Barell, V., Lubin, F., Modan, M., Greenberg, R.A. and Graham, S. Low-fiber intake as an etiologic factor in cancer of the colon. J. Natl. Cancer Inst. 55: 15–17, 1975.

    CAS  Google Scholar 

  25. Bjelke, E. Epidemiologic studies of cancer of the stomach, colon and rectum, with special emphasis on the role of diet. Scand. J. Gastr. 9: 1–235, 1974.

    Google Scholar 

  26. Bjelke, E. Case control study of cancer of the stomach, colon and rectum. Oncology 5: 320–333, 1970.

    Google Scholar 

  27. Dales, L.G., Freidman, G.D., Ury, H.K., Williams, S.R. and Grossman, S. Colorectal cancer and diet in blacks. Am. J. Epid. 106: 230–231, 1977.

    Google Scholar 

  28. Haenszel, W., Berg, J.W., Segi, M., Kurihara, M. and Locke, F.B. Large-bowel cancer in Hawaiian Japanese. J. Natl. Cancer Inst. 51: 1765–1777, 1973.

    CAS  Google Scholar 

  29. Kritchevsky, D. Modification by fiber of toxic dietary effects. Fed Proceed 36: 1692–1695, 1977.

    CAS  Google Scholar 

  30. Ershoff, B.H. Synergistic toxicity of food additives in rats fed a diet low in dietary fiber. J. Food Sci. 41: 949–951, 1976.

    CAS  Google Scholar 

  31. Watanabe, K., Bandaru, Reddy, S. and Kritchevsky, D. Effect of various dietary fibers and food additives on azoxymethane (AOM) or methylnitrosourea (MNU)-induced colon carcinogenesis in rats. Fed Proceed 37: 262, 1978.

    Google Scholar 

  32. Wilson, R.B., Hutcheson, D.P. and Wideman. Dimethylhydrazineinduced colon tumours in rats fed diets containing beef fat or corn oil with and without wheat bran. Am. J. Clin. Nutr. 30: 176–181, 1977.

    CAS  Google Scholar 

  33. Kritchevsky, D., Tepper, S.A. and Story, A.J.A. Symposium: Nutritional perspectives and atherosclerosis; Nonnutritive fiber and lipid metabolism. J. Food Sci. 40: 8–11, 1975.

    Article  CAS  Google Scholar 

  34. Rose, G., Blackburn, H., Keys, A., Taylor, H.L., Kannel, W.B., Paul, 0., Reid, D.D. and Stamler, J. Colon cancer and blood-cholesterol. Lancet: 180–183, 1974.

    Google Scholar 

  35. Morris, J.N., Marr, J.W. and Clayton, D.G. Diet and heart: A postscript. Br. Med. J. 2: 1307–1314, 1977.

    Article  CAS  Google Scholar 

  36. Eastwood, M.A., Fisher, N., Greenwood, C.T. and Hutchinson, J.B. Perspectives on the bran hypothesis. Lancet: 1029–1033, 1974.

    Google Scholar 

  37. Spiller, G.A. and Amen, R.J. Plant fibers in nutrition: Need for better nomenclature. Am. J. Clin. Nutr. 28: 675–676, 1965.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Clin. Epidem. — Chaim Sheba Medical Center Tel Hashomer, Tel Aviv University Medical School, Tel Aviv, Israel

    Baruch Modan M.D.

Authors
  1. Baruch Modan M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Brazilian Nutrition Society, Rio de Janeiro, Brazil

    Walter Santos , Nabuco Lopes , J. J. Barbosa  & Dagoberto Chaves , ,  & 

  2. National Food and Nutrition Institute and Associação Brasiliense de Nutrologia, Rio de Janeiro, Brazil

    José Carlos Valente

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer Science+Business Media New York

About this chapter

Cite this chapter

Modan, B. (1980). Protective Role of Fiber in Carcinogenesis. In: Santos, W., Lopes, N., Barbosa, J.J., Chaves, D., Valente, J.C. (eds) Nutritional Biochemistry and Pathology. Nutrition and Food Science, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1349-7_59

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1349-7_59

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1351-0

  • Online ISBN: 978-1-4757-1349-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation