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Morphological and Quantitative Aspects of Bone Formation and Mineralization

  • Conference paper
Bone Regulatory Factors

Part of the book series: NATO ASI Series ((NSSA,volume 184))

Abstract

Bone formation is a biphasic process. During the first phase, the osteoblasts secrete an organic matrix, called preosseous matrix or osteoid, made up of type I collagen and ground substance (proteoglycans, glycoproteins, non-collagenous proteins). During the second phase, mineralization occurs, transforming the osteoid into bone tissue. Analyzed from the morphological viewpoint, three main aspects must be taken into account in osteogenesis of cellular bone: osteoblast dynamics, namely the mechanism by which the osteoblasts modulate the bone appositional growth rate; osteoblast-osteocyte transformation; osteoblast control of collagen orientation.

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Author information

Authors and Affiliations

  1. Istituto di Anatomia umana normale, Università di Modena Policlinico, Via Del Pozzo 71, Modena, Italy

    Gastone Marotti

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  1. Gastone Marotti
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    Antonio Pecile (Professor of Pharmacology) (Professor of Pharmacology)

  2. Biophysics and Chemistry of Macromolecules, University of Trieste, Trieste, Italy

    Benedetto de Bernard (Head of the Dept. of Biochemistry) (Head of the Dept. of Biochemistry)

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© 1990 Springer Science+Business Media New York

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Marotti, G. (1990). Morphological and Quantitative Aspects of Bone Formation and Mineralization. In: Pecile, A., de Bernard, B. (eds) Bone Regulatory Factors. NATO ASI Series, vol 184. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1508-8_3

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  • DOI: https://doi.org/10.1007/978-1-4757-1508-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1510-1

  • Online ISBN: 978-1-4757-1508-8

  • eBook Packages: Springer Book Archive

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