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Modern Techniques for the Fractionation and Purification of Phospholipids from Biological Materials

  • Chapter
Lecithin

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 33))

Abstract

Glycerophospholipids have important roles in biological processes. In addition to forming the hydrophobic backbone of cell membranes, glycerophospholipids also participate actively in signal transduction. A number of receptors respond to agonist-binding by activation of a phospholipase C that hydrolyzes PtdIns 4,5-P2 to InsP3 and diacylglycerols (Berridge and Irvine, 1984; Berridge et al., 1985; Berridge, 1986; Nishizuka, 1984a, b; Hirasawa and Nishizuka, 1985; Abdel-Latif et al., 1985; Akhtar and Abdel-Latif, 1986). The InsP3 may increase cytosolic Ca2+ concentrations, thus activating a protein kinase and other reactions. The diacylglycerol stimulates protein kinase C.

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Authors and Affiliations

  1. Department of Physiological Chemistry, The Ohio State University, 1645 Neil Avenue, 214 Hamilton Hall, Columbus, Ohio, 43210, USA

    Lloyd A. Horrocks, Laura L. Dugan, Cheryl J. Flynn, Gianfrancesco Goracci, Serena Porcellati & Young Yeo

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  1. Lloyd A. Horrocks
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  2. Laura L. Dugan
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  4. Gianfrancesco Goracci
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  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin

  2. Medical School, University of Birmingham, Birmingham, UK

    G. Brian Ansell

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Horrocks, L.A., Dugan, L.L., Flynn, C.J., Goracci, G., Porcellati, S., Yeo, Y. (1987). Modern Techniques for the Fractionation and Purification of Phospholipids from Biological Materials. In: Hanin, I., Ansell, G.B. (eds) Lecithin. Advances in Behavioral Biology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1933-8_2

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  • DOI: https://doi.org/10.1007/978-1-4757-1933-8_2

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