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Efforts to Prevent Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 through Human Milk

Past, Present, and Future

  • Conference paper
Protecting Infants through Human Milk

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 554))

Abstract

About a third of mothers who are positive for human immunodeficiency virus (HIV) infect their newborn infants (UNAIDS/WHO 2002). Most vertical transmission occurs during gestation and delivery (Edgeworth & Ugen 2000). Breastfeeding by an HIV-positive woman adds an additional 14% to the risk of in utero and intrapartum transmission (Dunn et al. 1992). Alternatives to breastfeeding or modulation of breastfeeding techniques that are accessible, acceptable, and safe to use in low- and middle-income countries are in demand. Thus, research on making breastfeeding safer is a high priority. The purpose of this chapter is to review treatment approaches to decrease or eliminate HIV in human milk.

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References

  1. AIDS Clinical Trials Information Service. Available at http://www.actis.org. Accessed 12/2/02.

  2. Bass E. AIDS vaccines and HIV transmission via breastfeeding. Is there a role for vaccines in protecting infants against HIV in breast milk? AIDScience Vol. 1, No. 14, November 8, 2001. Available at http://aidscience.org.

    Google Scholar 

  3. Boelaert JR, Yaro S, Augustijns P, Meda N, Schneider YJ, Schols D, Mols R, De Laere EA, Van de Perre P. Chloroquine accumulates in breast-milk cells: potential impact in the prophylaxis of postnatal mother-to-child transmission of HIV-1. AIDS 2001;15:2205–2207.

    Article  PubMed  CAS  Google Scholar 

  4. Boisen F, Jorgensen AF. Pasteurization of HIV contaminated breast milk. Abstract No. LbPp122. XIII International AIDS Conference. Durban, South Africa; 2000.

    Google Scholar 

  5. Bultreys M, Nolan ML, Jamieson DJ, Dominguez K, Fowler MG. Advances in the prevention of mother-to-child HIV-1 transmission: Current issues, future challenges. AIDScience Vol. 2, No. 4, February 28, 2002. Available at http://aidscience.org.

  6. Chantry CJ, Morrison P, Panchula J, Rivera C, Hillyer G, Zorilla C, Diaz C. Effects of lipolysis or heat treatment on HIV-1 provirus in breast milk. J Acquir Immune Defic Syndr 2000;24:325–329.

    PubMed  CAS  Google Scholar 

  7. Denisova GF, Zerwanitzer M, Denisov DA, Spectorman E, Mondor I, Sattentau Q, Gershoni JM. Expansion of epitope cross-reactivity by anti-idiotype modulation of the primary humoral response. Mol Immunol 2000;37:53–58.

    Article  PubMed  CAS  Google Scholar 

  8. Dreisbach RH, Robertson WO. Handbook of Poisoning: Prevention, Diagnosis and Treatment. 12th Edition. Norwalk, CT: Appleton & Lange, 1987.

    Google Scholar 

  9. Dunn DT, Newell ML, Ades AE, Peckham CS. Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet 1992;340:585–588.

    Article  PubMed  CAS  Google Scholar 

  10. Edgeworth RL, Ugen KE. Immunopathological factors for vertical transmission of HIV-1. Pathobiology 2000;68:53–67.

    Article  PubMed  CAS  Google Scholar 

  11. Ford JE, Law BA, Marshall VM, Reiter B. Influence of the heat treatment of human milk on some of its protective constituents. J Pediatr 1977;90:29–35.

    PubMed  CAS  Google Scholar 

  12. Howett MK, Neely EB, Christensen ND, Wigdahl B, Krebs FC, Malamud D, Patrick SD, Pickel MD, Welsh PA, Reed CA, Ward MG, Budgeon LR, Kreider JW. A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses. Antimicrob Agents Chemother 1999;43:314–321.

    Article  PubMed  CAS  Google Scholar 

  13. Jeffery BS, Mercer KG. Pretoria pasteurisation: a potential method for the reduction of postnatal mother to child transmission of the human immunodeficiency virus. J Trop Pediatr 2000;46:219–223.

    Article  PubMed  CAS  Google Scholar 

  14. Jeffery BS, Webber L, Mokhondo KR, Erasmus D. Determination of the effectiveness of inactivation of human immunodeficiency virus by Pretoria pasteurization. J Trop Pediatr 2001;47:345–349.

    Article  PubMed  CAS  Google Scholar 

  15. Leroy V, Karon JM, Alioum A, Ekpini ER, Meda N, Greenberg AE, Msellati P, Hudgens M, Dabis F, Wiktor SZ. Twenty-four month efficacy of a maternal short-course zidovudine regimen to prevent mother-to-child transmission of HIV-1 in West Africa. AIDS 2002;16:631–641.

    Article  PubMed  CAS  Google Scholar 

  16. Madsen BF. Solar-powered device inactivates HIV in breast milk. AIDS Education Global Information System (AEGIS). Available at http://www.aegis.com/news/ads/2000/AD001616.html; 2000.

    Google Scholar 

  17. Mofenson LM, Burns DN. Passive immunization to prevent mother-infant transmission of human immunodeficiency virus: current issues and future directions. Pediatr Infect Dis J 1991;10:456–462.

    Article  PubMed  CAS  Google Scholar 

  18. Ogunbona FA, Onyeji CO, Bolaji OO, Torimiro SE. Excretion of chloroquine and desethylchloroquine in human milk. Br J Clin Pharmacol 1987;23:473–476.

    Article  PubMed  CAS  Google Scholar 

  19. Orloff SL, Wallingford JC, McDougal JS. Inactivation of human immunodeficiency virus type I in human milk: effects of intrinsic factors in human milk and of pasteurization. J Hum Lact 1993;9:13–17.

    Article  PubMed  CAS  Google Scholar 

  20. Papathakis PC, Rollins NC. Adequacy of feeding recommendations for infants of HIV-infected mothers: assessment of nutrient content, cost and preparation time of breastmilk replacements in the South African context. Oral Presentation (MoOrF1030). XIV International AIDS Conference. Barcelona, Spain; 2002.

    Google Scholar 

  21. Pennypacker C, Perelson AS, Nys N, Nelson G, Sessler DI. Localized or systemic in vivo heat inactivation of human immunodeficiency virus (HIV): a mathematical analysis. J Acquir Immune Defic Syndr Hum Retroviral 1995;8:321–329.

    Article  CAS  Google Scholar 

  22. Savarino A, Gennero L, Chen HC, Serrano D, Malavasi F, Boelaert JR, Sperber K. Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity. AIDS 2001;15:2221–2229.

    Article  PubMed  CAS  Google Scholar 

  23. Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother 1987;31:27–31.

    Article  PubMed  CAS  Google Scholar 

  24. UN AIDS. Fact Sheet. The Search for an HIV Vaccine. United Nations Special Session on HIV/AIDS. New York, June 2001. UNAIDS/WHO. AIDS Epidemic Update: December 2000. Geneva: World Health Organization; 2000.

    Google Scholar 

  25. UNAIDS/WHO. AIDS Epidemic Update: December 2002. Geneva: World Health Organization; 2002.

    Google Scholar 

  26. UNFPA/UNICEF/WHO/UNAIDS. New data on the prevention of mother-to-child transmission of HIV and their policy implications—Conclusions and recommendations. Report No. WHO/RHR/01.28; Geneva: World Health Organization; October 2000.

    Google Scholar 

  27. WHO/UNAIDS/UNICEF. Technical consultation on HIV and infant feeding implementation guidelines. Report of a meeting. Geneva, 20–22 April 1998. Geneva: World Health Organization; 1998.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Microbiology and Immunology, College of Medicine, M.S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, 17033, USA

    S. Urdaneta & M. K. Howett

  2. Department of Pediatrics, College of Medicine, Pennsylvania State University, Hershey, PA, USA

    C. M. Berlin

  3. Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

    C. M. Berlin

  4. Department of Obstetrics & Gynecology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

    M. K. Howett

Authors
  1. S. Urdaneta
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  2. C. M. Berlin
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  3. M. K. Howett
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Editor information

Editors and Affiliations

  1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    Larry K. Pickering MD

  2. Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

    Ardythe L. Morrow PhD

  3. Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico

    Guillermo M. Ruiz-Palacios MD

  4. Schneider Children’s Hospital at North Shore, Manhasset, New York, USA

    Richard J. Schanler MD

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© 2004 Springer Science+Business Media New York

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Urdaneta, S., Berlin, C.M., Howett, M.K. (2004). Efforts to Prevent Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 through Human Milk. In: Pickering, L.K., Morrow, A.L., Ruiz-Palacios, G.M., Schanler, R.J. (eds) Protecting Infants through Human Milk. Advances in Experimental Medicine and Biology, vol 554. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4242-8_68

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  • DOI: https://doi.org/10.1007/978-1-4757-4242-8_68

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3461-1

  • Online ISBN: 978-1-4757-4242-8

  • eBook Packages: Springer Book Archive

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