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Effects of Pancreas Transplantation on Secondary Complications of Diabetes

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Transplantation of the Pancreas

Abstract

Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD) in the Western world, responsible for more than 44% of new ESRD cases in the United States.1 Type 2 diabetes is currently responsible for the large majority of diabetic ESRD patients.2 Among patients with type 1 diabetes, 25% to 35% ultimately develop severe DN and a similar risk is found by long-term survivors of type 2 diabetes.2 Despite the beneficial effects of antihypertensive agents, in slowing the rate of progression of overt diabetic nephropathy,3–5 the number of diabetic patients requiring renal replacement therapy is substantially and continuously increasing.1 Thus, any therapeutic intervention able to reduce the risk of ESRD in diabetes can provide benefits in terms of mortality, morbidity, quality of life of patients, and healthcare costs.

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  1. Paola Fioretto
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  2. Michael Mauer
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  7. Xavier Navarro
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  9. A. Osama Gaber
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  10. Ann Cashion
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Editors and Affiliations

  1. Department of Surgery, University of Minnesota, 55455, Minneapolis, Minnesota, USA

    Rainer W. G. Gruessner MD (Professor) & David E. R. Sutherland MD, PhD (Professor) (Professor) &  (Professor)

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Fioretto, P. et al. (2004). Effects of Pancreas Transplantation on Secondary Complications of Diabetes. In: Gruessner, R.W.G., Sutherland, D.E.R. (eds) Transplantation of the Pancreas. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4371-5_16

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