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Bacterial Endotoxin as a Probe to Investigate Viral Induced Immune Deficiencies

  • Chapter
Endotoxin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

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Abstract

That viral induced immune deficiencies (VID) are a major medical problem is dramatically emphasized by the ongoing pandemic of acquired immune deficiency syndrome (AIDS). However, the ability to impair the immune system of the host is not limited to the human immune deficiency virus (HIV). The first report that viral infections may be the cause of clinically significant perturbations of immune reactivity was published long before AIDS was even dreamed of. Eighty years ago Clement von Pirquet reported that children with measles showed a transient anergy to tuberculin as evidenced by reduced skin tests. Since this pioneering work a vast array of human and animal viruses have been shown to suppress many parameters of immunological reactivity in infected hosts (for recent reviews, see 1, 27, 28, 32, 36).

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Author information

Authors and Affiliations

  1. Department of Biomedicine, Virology Section University of Pisa, Pisa, Italy

    M. Bendinelli, D. Matteucci, P. G. Conaldi & E. Soldaini

Authors
  1. M. Bendinelli
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  2. D. Matteucci
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  3. P. G. Conaldi
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  4. E. Soldaini
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1990 Springer Science+Business Media New York

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Bendinelli, M., Matteucci, D., Conaldi, P.G., Soldaini, E. (1990). Bacterial Endotoxin as a Probe to Investigate Viral Induced Immune Deficiencies. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_45

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5142-0

  • Online ISBN: 978-1-4757-5140-6

  • eBook Packages: Springer Book Archive

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