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Prolactin as an Immunomodulatory Hormone

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Advances in Psychoneuroimmunology

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

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Abstract

The first experimental observation indicating the effect of prolactin (PRL) on the thymus was made by Smith in 1930. He observed that the thymus gland of hypophysectomized (Hypox) rats ceased to grow and regressed in weight to less than half of controls in long surviving animals. On the other hand, partially hypophysectomized rats showed an absolute weight loss no greater than the controls. These and other observations triggered many investigators to study the influence of hormones on lymphoid tissues. However, the lack of purified hormone preparations and proper assays at the time posed insurmountable difficulties which led to contradictions and confusion.1 Studies on the regulatory effect of the pituitary gland on bone marrow function have a similar history.2 During the past decade neuroendocrine immunoregulatory mechanisms have been investigated with increasing interest and the influence of PRL on lymphoid tissue and immune function has been reviewed in recent years.3–8

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Authors and Affiliations

  1. Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

    Eva Nagy & Istvan Berczi

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  1. Eva Nagy
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  2. Istvan Berczi
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  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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© 1994 Springer Science+Business Media New York

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Nagy, E., Berczi, I. (1994). Prolactin as an Immunomodulatory Hormone. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_8

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  • DOI: https://doi.org/10.1007/978-1-4757-9104-4_8

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