Skip to main content

Design, Structure-Activity, Labelling and Purity in the Development of Receptor Interacting Radiohalogenated Tracers

  • Chapter
Chemists’ Views of Imaging Centers

Abstract

The design and development of new radiohalogenated tracers for in vivo measurement of brain receptor related processes is due, to its complexity, the work of pharmaceutical companies or large multidisciplinary research groups. For the development of radiopharmaceuticals generally a compound is chosen based on its known pharmacological properties and a strategy must be developed to introduce the radioisotope.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. Mertens, and M. Gysemans, CuI+ assisted nucleophilic exchange radiohalogenation: application and mechanistic approach, in: New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and regulatory Control, A.M. Emran, Plenum Press, New York and London (1991).

    Google Scholar 

  2. I. Nakatsuka, H. Saji, K. Shiba, H. Shimizu, M. Okuno, A. Yoshitake, and A. Yokoyama, In vitro evaluation of radioiodinated butyrophenones as radiotracer for dopamine receptor study, Life Sci, 41:1989–1997 (1987).

    Article  PubMed  CAS  Google Scholar 

  3. J.E. Leysen, W. Gommeren, J. Mertens, W.H.M.L. Luyten, P.J. Pauwels, M. Ewert, and P. Seeburg, Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I]-2′-iodospiperone, Psychopharmac., 110:27–36 (1993).

    Article  CAS  Google Scholar 

  4. J. Mertens, C. Piron, F. De Geeter, L. Christieans, R. Cantineau, M. Guillaume, and J. Leysen, Evaluation of pure 2′-125I-spiperone as a promising tracer for in vivo D2 receptor study with SPECT, J. NucL Med., 30:926 (1990).

    Google Scholar 

  5. J. Mertens, “Clustered lipophilic compensation” a new concept in the development of lipophilic radioiodinated and brominated receptor tracers, J. Lab. Comp. Ratiopharm., 30:363 (1991).

    Google Scholar 

  6. J.C. Baron, Y. Samson, D. Comar, C. Crouzel, P. Deniker, Y. Agid, Etude in vivo des récepteurs serotoninergiques centraux chez l’homme par tomographic à émission de positrons, Rev. Neurol., 141:537–545 (1985).

    PubMed  CAS  Google Scholar 

  7. C. Lemaire, R. Cantineau, M. Guillaume, A. Plenevaux, L. Christiaens, Fluorine-18-Altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats, J. Nucl. Med., 32:2266–2272 (1991).

    PubMed  CAS  Google Scholar 

  8. H. D’haenen, A. Bossuyt, J. Mertens, C. Bossuyt-Piron, M. Gysemans, and L. Kaufman, SPECT imaging of serotonin2 receptors in depression, Psychiat. Res: Neuroimaging., 45:227–237 (1992).

    Article  Google Scholar 

  9. M.R. Kilbourn, and M.R. Zalutsky, Research and clinical potential of receptor based radiopharmaceuticals, J. NucL Med., 26:655–662 (1985).

    PubMed  CAS  Google Scholar 

  10. J. Mertens, M. Gysemans, C. Piron, M. Thomas, High yield preparation of pure 2-radioiodo-ketanserin of high specific acitivity, a serotonin S2 receptor tracer for SPECT, J. Lab. Comp. Ratiopharm., 28:731–738 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mertens, J., Moereels, H., Gysemans, M., Terriere, D., Thomas, M., Leysen, J. (1995). Design, Structure-Activity, Labelling and Purity in the Development of Receptor Interacting Radiohalogenated Tracers. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9670-4_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9672-8

  • Online ISBN: 978-1-4757-9670-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics