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Transforming Growth Factor-β

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Transforming growth factor-β (TGF-β) is generally acknowledged to be the cytokine with the broadest range of activities in repair of injured tissue, based both on the variety of cell types that produce and/or respond to it and on the spectrum of its cellular responses (Roberts and Sporn, 1990). TGF-β is released from degranulating platelets and secreted by all of the major cell types participating in the repair process, including lymphocytes, macrophages, endothelial cells, smooth muscle cells, epithelial cells, and fibroblasts (see Fig. 1). A unique feature of this molecule is that its autoinduction results in sustained expression at the site of a wound and extends the effectiveness of both the initial burst of endogenous TGF-β released upon injury and exogenous TGF-β that might be applied to a wound. The ability of TGF-β to improve and/or accelerate tissue repair has been studied extensively in a variety of animal models of both normal and impaired healing. A limited number of clinical trials are in progress, but it is anticipated that many new applications for TGF-β will ultimately be found, once problems with appropriate timing and formulation can be solved.

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Authors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland, 20892-5055, USA

    Anita B. Roberts & Michael B. Sporn

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  1. Anita B. Roberts
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  2. Michael B. Sporn
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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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© 1988 Springer Science+Business Media New York

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Roberts, A.B., Sporn, M.B. (1988). Transforming Growth Factor-β. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_8

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  • DOI: https://doi.org/10.1007/978-1-4899-0185-9_8

  • Publisher Name: Springer, Boston, MA

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