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Membrane-Induced Calcium-Oxalate Crystal Nucleation

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Urolithiasis

Abstract

Calcium oxalate (CaOx) crystals experimentally induced in rat kidneys as well as those found in human kidneys are almost always associated with PAS and colloidal iron-positive material (1). Transmission electron microscopy of the crystalline deposits in rat renal tubules revealed the associated material to consist of amorphous as well as membranous cellular degradation products (MCDP). Since CaOx relative supersaturation (RSS) of both stoneforming rat as well as human urine is much less than required for homogeneous nucleation of CaOx, it is suggested that crystal nucleation in urolithiasis is heterogeneous (2). Since the CaOx-crystal MCDP association appears universal, we decided to investigate, in vitro, the possibility of membranes playing a role in crystal nucleation. We used renal brush border membrane (BBM) because renal proximal tubules have been implicated in urolithiasis (3).

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References

  1. SR Khan and RL Hackett, Experimental calcium oxalate nephrolithiasis, is it a model for human stone disease? Scanning Eleeton Micros. II: 759 (1985).

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  2. B Finlayson, Physico-chemical aspects of urolithiasis, Kidney Internat. 13: 344 (1978).

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  3. RS Malek and WH Boyce, Intranephronic calculosis: its significance and relationship to matrix in nephrolithiasis, J. Urol. 109: 5551 (1973).

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  4. PG Werness, CM Brown, LH Smith, and B Finlayson, Equil 2: a BASIC computer program for the calculation of urinary saturation, J. Urol. 134: 1242 (1985).

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA

    S. R. Khan & R. L. Hackett

Authors
  1. S. R. Khan
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  2. R. L. Hackett
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Editor information

Editors and Affiliations

  1. University of British Columbia, Vancouver, British Columbia, Canada

    Valerie R. Walker , Roger A. L. Sutton  & E. C. Bert Cameron ,  & 

  2. Southwestern Medical Center, University of Texas, Dallas, Texas, USA

    Charles Y. C. Pak

  3. King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    William G. Robertson

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© 1989 Springer Science+Business Media New York

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Khan, S.R., Hackett, R.L. (1989). Membrane-Induced Calcium-Oxalate Crystal Nucleation. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_34

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  • DOI: https://doi.org/10.1007/978-1-4899-0873-5_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0875-9

  • Online ISBN: 978-1-4899-0873-5

  • eBook Packages: Springer Book Archive

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