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Lipoprotein Lipase Activity in the Pathological Metabolism of Lipoproteins

  • Chapter
Esterases, Lipases, and Phospholipases

Part of the book series: NATO ASI Series ((NSSA,volume 266))

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Abstract

Many of the clinical features of defective lipoprotein lipase activity were known well before the present century, particularly the milky appearance of serum. This was as the result of the use of venesection as a means of treatment of such disorders as abdominal pain, diabetes, alcoholism, and glomerulonephritis (reference 1 cites many early reports). The syndrome of familial lipoprotein deficiency (FLLD) was not, however, first clearly described until the 1930’s [2, 3]. Havel and Gordon first showed that its basis was defective lipoprotein lipase activity [4]. Only recently has it also been appreciated that a similar syndrome can result from a defect in apolipoprotein CII, the circulating activator of lipoprotein lipase [5]. Lipoprotein lipase deficiency with an autoimmune basis has also been described [6].

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References

  1. Fisher B. Uber lipamie und cholesteremie, sowie uber des pancreas und der leber bei diabetes mellitus. Virchow’s Archiv. 172: 1903; 3071.

    Google Scholar 

  2. Burger M., Grutz 0. Uber hepatosplenomegale lipoidose mit xanthomatosen veranderunger in haut un schleimhaut. Archive. Dermatol Syph 166: 1932; 542–475.

    Google Scholar 

  3. Holt L.E., Aylward F.X. Timbres H.G. Idiopathic familial lipaemia. John Hopkins Hosp. Bull 64: 1939; 279–314.

    Google Scholar 

  4. Havel R.J., Gordon R. J. Idiopathic hyperlipidaemia. Metabolic studies in an affected family. J. Clin. Invest. 39: 1960; 1777–1790.

    Article  PubMed  CAS  Google Scholar 

  5. Breckenridge W.C., Little A., Steiner G., Chow A. Poapst M. Hypertriglyceridaemia associated with deficiency of apolipoprotein C-II. N. Engl. J. Med. 298: 1978; 1265–1273.

    Article  PubMed  CAS  Google Scholar 

  6. Glueck C.J., Kaplan A.P., Levy R.I., Greten H., Gralnick H.,Fredrickson D.S. A new mechanism of exogenous hypertriglyceridaemia. Ann. Int. Med. 7: 1969; 1051–1057.

    Google Scholar 

  7. Babirak S.P., Iverius P-H., Fjimoto W.Y., Brunzell J.D. Detection and characterisation of the heterozygote state for lipoprotein lipase deficiency. Arteriosclerosis 9: 1989; 326–334.

    Article  PubMed  CAS  Google Scholar 

  8. Hayden M., De Braekeleer M., Henderson H.E., Kastelein J. Molecular geography of inherited disorders of lipoprotein metabolism: lipoprotein lipase deficiency and familial hypercholesterolaemia in Molecular Genetics of Coronary Artery Disease. Candidate Genes and Processes in Atherosclerosis. Lewis A.J., Rotter J.I., Sparkes R.S. eds., Monogr. Hum. Genet. Karger, Basel 14: 1992; 350–362.

    Google Scholar 

  9. Demant T., Gaw A., Watts G.F. et al Metabolism of apo B-100-containing lipoproteins in familial hyperchylomicronaemia. J. Lipid. Res. 34: 1993; 147–156.

    PubMed  CAS  Google Scholar 

  10. Durrington P.N. Hypertriglyceridaemia. Chapter 7 in Hyperlipidaemia. Diagnosis and Management. Wright, London 1989; 135–156.

    Google Scholar 

  11. Havel R.J. Pathogenesis differentiation and management of hypertriglyceridaemia. Adv. Intern. Med. 15: 1969; 117–154.

    PubMed  CAS  Google Scholar 

  12. Braganza J.M. Pancreatic disease: a casualty of hepatic ‘detoxification’? Lancet ii: 1983; 1000–1002.

    Google Scholar 

  13. Durrington P.N., McIver J.E., Holdsworth G., Galton D.J. Severe hypertriglyceridaemia associated with pancytopenia and lipoprotein lipase deficiency. Ann. Int. Med. 94: 1981; 211–212.

    Article  CAS  Google Scholar 

  14. Bengtsson-Olivecrona G., Olivecrona T. Assay of lipoprotein lipase and hepatic lipase Chapter 7a in Lipoprotein Analysis: A Practical Approach. Converse C.A., Skinner E.R. eds. Oxford University Press, Oxford, 1993; 169–185.

    Google Scholar 

  15. Zambon A., Torres A., Bijouet S., Gange C., Moorjani S., Lupien P.J., Hayden M.R., Brunzell J.D. Prevention of raised ‘low-density’ lipoprotein cholesterol in a patient with familial hypercholesterolaemia and lipoprotein lipase deficiency. Lancet 341: 1993; 119–1121

    Article  Google Scholar 

  16. Mitropoulos K.A., Miller G.J., Watts G.F., Durrington P.N. Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency. Atherosclerosis 95: 1992; 119–125.

    Article  PubMed  CAS  Google Scholar 

  17. Meade T.W., Mellows S.M., Brozovic M. et al Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet ií: 1986; 533–537.

    Google Scholar 

  18. Brown M.S., Herz J., Kowal R.C., Goldstein J.L. The low-density lipoprotein receptor-related protein: double agent or decoy ? Curr. Opin. Lipidol. 2: 1991; 65–72.

    Article  CAS  Google Scholar 

  19. Beisiegel U. Apolipoproteins as ligands for lipoprotein receptors. Chapter 10 in Structure and Function of Apolipoproteins ed Rosseneu M. CRC Press Inc. Boca Raton 1992; 269–294.

    Google Scholar 

  20. Karpe F., Olivecrona T., Walldius G., Hamsten A. Lipoprotein lipase in plasma after an oral fat load: relation to free fatty acids. J. Lipid Res. 33: 1992; 975–984.

    PubMed  CAS  Google Scholar 

  21. Pykolisto O.J., Smith P.H., Brunzell J.D. Determinants of human adipose tissue lipoprotein lipase: effects of diabetes and obesity on basal and diet induced activity J. Clin. Invest. 56: 1975; 1108 1117.

    Google Scholar 

  22. Auwerx J.H., Babirak S.P., Hopkanson J.E., Stahnke G., Will H., Deeb S.S., Brunzell J.D. Coexistance of abnormalities of hepatic lipase and lipoprotein lipase in a large family. Am. J. Hum. Genet. 46: 1990; 470–477.

    PubMed  CAS  Google Scholar 

  23. Durrington P.N., Twentyman O.P., Braganza J.M., Miller J.P. Hypertriglyceridaemia and abnormalities of triglyceride catabolism persisting after pancreatitis. Int. J. Pancreatol. 1: 1986; 195–203.

    CAS  Google Scholar 

  24. Huttunen J.K., Ehnholm C., Kekki M., Nikkila E.A. Post-heparin lipoprotein lipase and hepatic lipase in normal subjects and in patients with hypertriglyceridaemia: correlations to sex, age and various parameters of triglyceride metabolism. Clin. Sci. Mol. Med. 50: 1976; 249–260.

    PubMed  CAS  Google Scholar 

  25. Krauss R.M., Levy R.I., Fredrickson D.S. Selective measurement of two lipase activities in postheparin plasma from normal subjects and patients with hyperlipoproteinaemia. J. Clin. Invest. 54: 1974; 1107–1124.

    Article  PubMed  CAS  Google Scholar 

  26. Wojciechowski A.P., Farrall M., Cullen P. et al Familial combined hyperlipidaemia linked to the apolipoprotein AI-CIII-AIV gene cluster on chromosome 11823-q24. Nature 349: 1991; 161–164.

    Article  PubMed  CAS  Google Scholar 

  27. Hulley S.B., Rosenman R.H., Bawol R.D., Braid R.J. Epidemiology as a guide to clinical decision. The association between triglyceride and coronary heart disease. N. Engl. J. Med. 302: 1980; 1383–1389.

    Article  PubMed  CAS  Google Scholar 

  28. Huttunen J.K., Manninen V., Tenkanen L., Heinonen O.P., Koskinen P., Frick M.H. Drug induced changes in HDL-cholesterol and coronary heart disease. Experinnces from the Helsinki Heart Study in High Density Lipoproteins and Atherosclerosis II Miller N.E. Ed, Excerpta Medica, Amsterdam 1989, 191–198.

    Google Scholar 

  29. Neary R., Bhatnagar D., Durrington P.N., Ishola M., Arrol S., Mackness M.I. An investigation of the role of lecithin: cholesterolacyl transferase and triglyceride-rich lipoproteins in the metabolism of pre-beta high density lipoproteins. Atherosclerosis 89: 1991; 35–48.

    Article  PubMed  CAS  Google Scholar 

  30. Ruys T., Sturgess I., Shaikh M., Watts G.F., Nordestgaard B.G., Lewis B. Effects of exercise and fat ingestion on high density lipoprotein production by peripheral tissues. Lancet 334: 1989; 1119–1121.

    Article  Google Scholar 

  31. Editorial. Cholesteryl ester transfer protein. Lancet; 338: 1991, 666–667

    Article  Google Scholar 

  32. Bhatnagar D., Durrington P.N., Channon K.M., Prais H., Mackness M.I. Increased transfer of cholesteryl esters from high density lipoproteins to low density and very low density lipoproteins in patients with angiographic evidence of coronary artery disease. Atherosclerosis 98: 1992; 25–32.

    Article  Google Scholar 

  33. Bhatnagar D., Durrington P.N., Mackness M.I., Arrol S., Winocour P.H., Prais H. Effects of treatment of hypertriglyceidaemia with gemfibrozil on serum lipoproteins and the transfer of cholesteryl ester from high density lipoproteins to low density lipoproteins. Athersclerosis 92: 1992; 49–57

    Article  CAS  Google Scholar 

  34. Taylor T.G., Holdsworth G., Galton D.J. Clofibrate increases lipoprotein-lipase activity in adipose tissue of hypertriglyceridaemic patients. Lancet 11: 1977; 1106–1107.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine Manchester Royal Infirmary, University of Manchester, Manchester, M13 9WL, UK

    Paul N. Durrington

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  1. Paul N. Durrington
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Editor information

Editors and Affiliations

  1. University of Manchester, Manchester, UK

    M. I. Mackness

  2. University of Bordeaux II, Bordeaux, France

    M. Clerc

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© 1994 Springer Science+Business Media New York

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Durrington, P.N. (1994). Lipoprotein Lipase Activity in the Pathological Metabolism of Lipoproteins. In: Mackness, M.I., Clerc, M. (eds) Esterases, Lipases, and Phospholipases. NATO ASI Series, vol 266. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0993-0_16

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  • DOI: https://doi.org/10.1007/978-1-4899-0993-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0995-4

  • Online ISBN: 978-1-4899-0993-0

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