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Immunopharmacological Treatment during Pregnancy and Lactation

  • Chapter
Immunopharmacology in Autoimmune Diseases and Transplantation

Abstract

Connective tissue diseases have a predilection for the female sex and often affect women of childbearing age. The concurrence of pregnancy and connective tissue disease may represent a hazard both to mother and child. Underlying disease processes will add to the physiological changes of pregnancy and in some cases aggravate symptoms in the pregnant patient. This is a risk in systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), and progressive systemic sclerosis (PSS). On the other hand, the fetus may be affected by maternal systemic disease and/or vasculopathy of the placenta associated with connective tissue disease. Placental transfer of maternal autoantibodies may cause neonatal disease from SLE (Lockshin, 1985). Thus both patient and clinician have to face special demands resulting from the interaction between pregnancy and a complex disease process.

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References

  • Abramowsky, C. R., Vegas, M. E., Swinehart, G., and Gyves, M. T., 1980, Decidual vasculopathy of the placenta in systemic lupus erythematosus, N. Engl. J. Med. 303:668–672.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, P. O., 1987, Corticosteroid use by breast-feeding mothers, Clin. Pharm. 6:445.

    PubMed  CAS  Google Scholar 

  • Azad Khan, A. K., and Truelove, S. C.,1979, Placental and mammary transfer of sulphasalazine, Br. Med. J. 2:1553.

    Article  Google Scholar 

  • Beitins, I. Z., Bayard, F., Ances, I. G., Kowarski, A., Migeon, C. J., 1972, The transplacental passage of prednisone and prednisolone in pregnancy near term, J. Pediatr. 81:936–945.

    Article  PubMed  CAS  Google Scholar 

  • Bell, R. A. F., Dale, I. M., 1976, Gold secretion in maternal milk, Arthritis Rheum 19:1374.

    Article  PubMed  CAS  Google Scholar 

  • Bennett, P. N., ed., 1988, Drugs and Human Lactation, Elsevier, Amsterdam: pp. 286–287.

    Google Scholar 

  • Berlin, C. M., Jr., Kaiser, D. G., and Demers, L., 1979, Excretion of prednisone and prednisolone in human milk, Pharmacologist 21:264.

    Google Scholar 

  • Blau, S. P., 1973, Metabolism of gold during lactation, Arthritis Rheum. 16:777–778.

    Article  PubMed  CAS  Google Scholar 

  • Bogaert, M. C., and Thiery, M., 1983, Pharmakokinetics and pregnancy, Eur. J. Obstet. Gynecol Reprod. Biol 16:229–235.

    Article  PubMed  CAS  Google Scholar 

  • Bongiovanni, A. M., and McPadden, A. J., 1960, Steroids during pregnancy and possible fetal consequences, Fertil. Steril. 11: 181–186.

    PubMed  CAS  Google Scholar 

  • Briggs, G. G., Freeman, R. K., Yaffe, S. J., eds., 1986, in: Drugs in Pregnancy and Lactation, 2nd Edition, Williams and Wilkins, Baltimore, pp. 112–113.

    Google Scholar 

  • Christophidis, N., 1984, Methotrexate, Clin. Rheum, Dis. 10:401–415.

    CAS  Google Scholar 

  • Cockburn, I., Krupp, P., and Monka, G., 1989, Present experience of Sandimmun in pregnancy, Transplant. Proc. 21:3730–3732.

    PubMed  CAS  Google Scholar 

  • Cohen, D., Orzel, J., 1981, Infants of mothers receiving gold therapy, Arthritis Rheum. 24:104–105.

    Article  PubMed  CAS  Google Scholar 

  • Corazza, G. R., Gasbarrini, G., DiNisio, Q., and Zulli, P., 1982, Cimetidine in peptic ulcer therapy during pregnancy, Clin. Trials J. 19:91–93.

    Google Scholar 

  • Coté, C. J., Meuwissen, H. J., Pickering, R. J., 1974, Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy, J. Pediatr. 85:324–328.

    Article  PubMed  Google Scholar 

  • Coulam, C. B., Mayer, T. P., Jiang, N. S., and Zinck, H., 1982, Breast feeding after renal transplantation, Transplant Proc. 13: 605–609.

    Google Scholar 

  • Crawhall, J. C., Scowen, E. F., Thompson, C. J., 1967, Dissolution of cystine stones during D-penicillamine treatment of a pregnant patient with cystinuria, Br. Med. J. 1:216–218.

    Article  Google Scholar 

  • Davison, J. M., Dellagrammatikas, H., and Parkin, J. M., 1985, Maternal azathioprine therapy and depressed haemopoiesis in the babies of renal allograft patients, Br. J. Obstet. Gynaecol. 92:233–239.

    Article  PubMed  CAS  Google Scholar 

  • Dencker, L., Lindquist, N. G., 1975, Distribution of labeled chloroquine in the inner ear, Arch. Otolaryngol 101:185–188.

    Article  PubMed  CAS  Google Scholar 

  • Durodola, J. I., 1979, Administration of cyclophosphamide during late pregnancy and early lactation: A case report, J. Natl Med. Assoc. 71:165–166.

    PubMed  CAS  Google Scholar 

  • Endler, M., Derfler, K., Schaller, A., and Nowotny, C., 1987, Schwangerschaft und Geburt nach Nierentransplantation unter Cyclosporin A, Gebrutsch u. Frauenheilk. 660-663.

    Google Scholar 

  • Ette, E. I., Essien, E. E., Ogonor, J. I., and Brown-Awala, E. A., 1987, Chloroquine in human milk, J. Ctin. Pharmacol 27: 499–502.

    Article  CAS  Google Scholar 

  • Flechner, S. M., Katz, A. R., Rogers, A. J., van Buren, C., Kahan, B. D., 1985, The presence of cyclosporine in body tissues and fluids during pregnancy, Am. J. Kidney Dis. 5:60–63.

    PubMed  CAS  Google Scholar 

  • Førre, Ø, Waalen, K., Rugstad, H. E., Berg, K. J., Solbu, D., Kåss, E., 1988, Cyclosporine A in rheumatoid arthritis, Springer Semin. lmmunopathol 10:263–277.

    Article  Google Scholar 

  • Fraga, A., Mintz, G., Orozco, J., Orozco, J. H., Sterility and fertility rates, fetal wastage and maternal morbidty in systemic lupus erythematosus, J. Rheumatol 1:293–298.

    Google Scholar 

  • Freyberg, R., 1972, Gold therapy for rheumatoid arthritis, in: Arthritis and allied conditions (J. L. Hollander, ed.), Lea and Febiger, Philadelphia, pp. 455–482.

    Google Scholar 

  • Githens, J. H., Rosenkrantz, J. G., Tunnock, S. M., 1965, Teratogenic effects of azathioprine, J. Pediatr. 66:959–961.

    Article  PubMed  CAS  Google Scholar 

  • Greenberg, L. H., and Tanaka, K. R., 1964, Congenital anomalies probably induced by cyclophosphamide, J. Am. Med. Assoc. 188:423–426.

    Article  CAS  Google Scholar 

  • Gregory, M. C., and Mansell, M. A., 1983, Pregnancy and cystinuria, Lancet 2:1158–1160.

    Article  PubMed  CAS  Google Scholar 

  • Grischke, E., Kaufmann, M., Dreikorn, K., Linderkamp, O., Kubli, F., 1986, Erfolgreiche Schwangerschaft bei Nierentransplantation und Cyclosporin A, Geburtshilfe Frauenheilk. 46:176–179.

    Article  CAS  Google Scholar 

  • Hadi, H. A., Stafford, C. R., Williamson, J. R., Fadel, H. E., and Devoe, L. D., 1986, Pregnancy outcome in renal transplant recipients, South. Med. J. 79:959–964.

    Article  PubMed  CAS  Google Scholar 

  • Haerr, R. W., and Pratt, A. T., 1985, Multiagent chemotherapy for sarcoma diagnosed during pregnancy, Cancer 56:1028–1033.

    Article  PubMed  CAS  Google Scholar 

  • Hart, C. N., and Naunton, R. E., 1964, The ototoxicity of chloroquine phosphate, Arch. Otolaryngol Head Neck Surg. 80:407–412.

    Article  CAS  Google Scholar 

  • Hawkins, D. E., 1983, Prescribing in pregnancy, in: Drugs and Pregnancy (D. F Hawkins, ed.), Churchill Livingstone, Edinburgh, pp. 41–52.

    Google Scholar 

  • Hayslett, J. P., and Lynn, R. I., 1980, Effect of pregnancy in patients with lupus nephropathy, Kidney Int. 18:207–220.

    Article  PubMed  CAS  Google Scholar 

  • Hensleigh, P. A., and Kauffman, R. E., 1977, Maternal absorption and placental transfer of sulfasalazine, Am. J. Obstet. Gynecol. 127:443–444.

    PubMed  CAS  Google Scholar 

  • Houser, M. T., Fish, A. J., Tagatz, G. E., Willams, P. P., and Michael, A. F., 1980, Pregnancy and systemic lupus erythematosus, Am. J. Obstet. Gynecol 138:409–413.

    PubMed  CAS  Google Scholar 

  • Jarnerot, G., and Into-Malmberg, M. B., 1979, Sulphasalazine treatment during breast feeding, Scand. J. Gastroenterol 14: 869–871.

    Article  PubMed  CAS  Google Scholar 

  • Jarnerot, G., Into-Malmberg, M. B., Esbjoerner, E., 1981a, Placental transfer of sulphasalazine and sulphapyridine and some of its metabolites, Scand. J. Gastroenterol. 16:693–697.

    Article  PubMed  CAS  Google Scholar 

  • Jarnerot, G., Andersen, S., Esbjoerner, E., Sandstroem, B., Brodersen, R., 1981b, Albumin reserve for binding of bilirubin in maternal and cord serum under treatment with sulphasalazine, Scand. J. Gastroent. 16:1049–1055.

    Article  PubMed  CAS  Google Scholar 

  • Johns, D. G., Rutherford, L. D., Keighton, P. C., Vogel, C. L., 1972, Secretion of methotrexate into human milk, Am. J. Obstet. Gynecol. 112:978–980.

    PubMed  CAS  Google Scholar 

  • Juchau, M. R., Chao, S. T., and Omiecinski, C. J., 1980, Drug metabolism by the human fetus, Clin. Pharmacol. 5:320–339.

    Article  CAS  Google Scholar 

  • Katz, F., and Duncan, B. R., 1975, Entry of prednisone into human milk, N. Engl. J. Med. 293:1154.

    Article  PubMed  CAS  Google Scholar 

  • Kirshon, B., Wasserstrum, N., Willis, R., Herman, G. E., and McCabe, E. R. B., 1988, Teratogenic effects of first-trimester cyclophosphamide therapy. Obstet. Gynecol. 72:462–464.

    PubMed  CAS  Google Scholar 

  • Klintmalm, G., Althoff, P., Appleby, G., and Segerbrandt, E., 1984, Renal function in a newborn baby delivered of a renal transplant patient taking Cyclosporine, Transplantation 38:98–99.

    Article  Google Scholar 

  • Kozlowski, R. D., Steinbrunner, J. V, MacKenzie, A. H., Clough, J. D., Wilke, W. S., and Segal, A. M., 1990, Outcome of first trimester exposure to low-dose methotrexate in eight patients with rheumatic disease, Am. J. Med. 88:589–592.

    Article  PubMed  CAS  Google Scholar 

  • Levy, G., and Hayton, W. L., 1973, Pharmacokinetic aspects of placental drug transfer, in: Fetal Pharmacology (L. Boreus, ed., Raven Press, New York, pp. 29–39.

    Google Scholar 

  • Levy, M., Buskila, D., Gladman, D. D., Urowitz, M. B., and Koren, G., 1991, Pregnancy outcome following first trimester exposure to chloroquine, Am. J. Perinatol. 8:174–178.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, G. J., Lamont, C. A. R., Lee, H. A., and Slapak, M., 1983, Successful pregnancy in a renal transplant recipient taking cyclosporine A, Br. Med. J. 286:603.

    Article  CAS  Google Scholar 

  • Lewis, P. J., and Hurden, E. L., 1983, Drugs and breast feeding, in: Drugs and Pregnancy (D. F Hawkins, ed., Churchill Livingstone, Edinburgh, pp. 204–228.

    Google Scholar 

  • Linares, A., Zarranz, J. J., Rodriguez-Alarcon, J., and Diaz-Perez, J. L., 1979, Reversible cutis laxa due to maternal D-penicillamine treatment, Lancet 2:43.

    Article  PubMed  CAS  Google Scholar 

  • Lockshin, M. D, 1985, Lupus pregnancy, Clin. Rheum. Dis. 11:611–632.

    PubMed  CAS  Google Scholar 

  • Lockshin, M. D., Reinitz, E., Druzin, M. L., Murrman, M., and Estes, D., 1984, Case-control prospective study demonstrating absence of lupus exacerbation during or after pregnancy, Am. J. Med. 77:893–898.

    Article  PubMed  CAS  Google Scholar 

  • Logaridis, T. E., Doran, T. A., Scott, J. G., Gare, D. G., and Comtesse, C., 1983, The effect of maternal steroid administration on fetal platelet count in immunologie trobocytopenic purpura, Am. J. Obstet. Gynecol. 145:147–151.

    PubMed  CAS  Google Scholar 

  • Lubbe, W. E., Palmer, S. J., Butler, W. S., Liggins, G. C., 1983, Fetal survival after prednisone suppression of maternal lupus-anticoagulant, Lancet 1:1361–1363.

    Article  PubMed  CAS  Google Scholar 

  • Lyle, W. H., Penicillamine in pregnancy, Lancet 1:606.

    Google Scholar 

  • MacKenzie, A. H., 1983, Antimalarial drugs for rheumatoid arthritis (Oral gold symposium), Am. J. Med. 75:48–58.

    Article  PubMed  CAS  Google Scholar 

  • Maracek, Z., and Graf, M., 1976, Pregnancy in penicillamine treated patients with Wilson’s disease, N. Engl. J. Med. 295:841–842.

    Google Scholar 

  • Mason, R. J., Thomson, A. W., Whiting, P. H., Gray, E. S., Brown, P. A. J., Catto, G. R. D., Simpson, J. G., 1985, Cyclosporine-induced fetotoxicity in the rat, Transplantation 39:9–12.

    PubMed  CAS  Google Scholar 

  • Meehan, R. T., Dorsey, J. K., 1987, Pregnancy among patients with systemic lupus erythematosus receiving immunosuppressive therapy, J. Rheumatol 14:252–258.

    PubMed  CAS  Google Scholar 

  • Mjølnerød, O. K., Rasmussen, K., Dommerud, S. A., and Gjeruldsen, S. T., 1971, Congenital connective tissue defect probably due to D-penicillamine treatment in pregnancy, Lancet 1:673–675.

    Article  PubMed  Google Scholar 

  • Milunsky, A., Graef, J. W., Gaynor, M. E., 1968, Methotrexate-induced congenital malformations, J. Pediatr. 72:790–795.

    Article  PubMed  CAS  Google Scholar 

  • Mintz, G., Niz, J., Gutierrez, G., Garcia-Alonso, A., and Karchmer, S., 1986, Prospective study of pregnancy in systemic lupus erythematosus. Results of a multidisciplinary approach, J. Rheumatol 13:732–739.

    PubMed  CAS  Google Scholar 

  • Mirkes, P. E., 1985, Cyclophosphamide teratogenesis: A review, Teratogen. Carcinogen. Mutagen. 5:75–88.

    Article  CAS  Google Scholar 

  • Miyamoto, T., Miyaji, S., Horiuchi, Y., Hara, M., Ishihara, K., 1974, Gold therapy in bronchial asthma—special emphasis upon blood levels of gold and its teratogenicity, Nippon Noika Gakkai Zaashi 63:1190.

    Article  CAS  Google Scholar 

  • Mogadam, M., Dobbins, W. O., Korelitz, B. I., and Ahmed, S. W., 1981, Pregnancy in inflammatory bowel disease: Effect of sulfasalazine and corticosteroids on fetal outcome, Gastroenterology 80:72–76.

    PubMed  CAS  Google Scholar 

  • Møller-Madsen, B., Danscher, G., Uldbjerg, N., and Allen, J. G., 1987, Autometallographic demonstration of gold in human fetal liver and placenta, Rheumatol. Int. 7:47–48.

    Article  PubMed  Google Scholar 

  • Murphy, B. E. P., Clark, S. I., Donald, I. R., Pinsky, M., and Vedady, D., 1974, Conversion of maternal cortisol to cortisone during placental transfer to the human fetus, Am. J. Obstet. Gynecol. 118:538–541.

    PubMed  CAS  Google Scholar 

  • Nation, R. L., Hackett, L. P., Dusci, L. J., and Ilett, K. E., 1984, Excretion of hydroxychloroquine in human milk, Br. J.J. Clin. Pharmacol 17:368–369.

    Article  CAS  Google Scholar 

  • Nelis, G. E., 1989, Diarrhoea due to 5-aminosalicylic acid in breast milk, Lancet 1:383.

    Article  PubMed  CAS  Google Scholar 

  • Nicholson, H., 1968, Cytotoxic drugs in pregnancy, J. Obstet. Gynaecol. Br. Commonw. 75:307–312.

    Article  PubMed  CAS  Google Scholar 

  • Nishimura, H., and Tanimura, T., 1976, Information on prenatal hazards of drugs, in: Clinical aspects of the teratogenicity of drugs, Elsevier, New York, pp. 100–121.

    Google Scholar 

  • Osathonondh, A., Tuchinsky, D., Kamali, H., Fencl, M. D., Taeusch, H. W., 1977, Dexamethasone levels in treated pregnant women and newborn infants, J. Pediatr. 90:617–620.

    Article  Google Scholar 

  • Ost, L., Wettrell, G., Bjørkheim, I., and Rane, A., 1985, Prednisolone excretion in human milk, J. Pediatr. 106:1008–1011.

    Article  PubMed  CAS  Google Scholar 

  • Østensen, M., Brown, N. D, Chiang, P. K., Aarbakke, J., 1985, Hydroxychloroquine in human breast milk, Eur. J. Clin. Pharmacol. 28:357.

    Article  PubMed  Google Scholar 

  • Østensen, M., Skavdal, K., Myklebust, G., Tomassen, Y., Aarbakke, J., 1986, Excretion of gold into human breast milk, Eur. J. Clin. Pharmacol. 31:251–252.

    Article  PubMed  Google Scholar 

  • Palmer, R. G., Dore, C. J., and Denman, A. M., 1984, Chlorambucil-induced chromosome damage to human lymphocytes is dose dependent and cumulative, Lancet 1:246–249.

    Article  PubMed  CAS  Google Scholar 

  • Parke, A. L., 1988, Antimalarial drugs, systemic lupus erythematosus and pregnancy, J. Rheumatol. 15:607–610.

    PubMed  CAS  Google Scholar 

  • Paufique, L., and Magnard, P., 1969, Retinal degeneration in two children following preventive antimalarial treatment of mother during pregnancy, Bull. Soc. Opththalmol Fr. 69:466–467.

    CAS  Google Scholar 

  • Penn, I., Makowski, E. L., and Harris, P., 1980, Parenthood following renal transplantation, Kidney Int. 18:221–233.

    Article  PubMed  CAS  Google Scholar 

  • Perucca, E., and Crema, A., 1982, Plasma protein binding of drugs during pregnancy, Clin. Pharmacokin. 7:336–352.

    Article  CAS  Google Scholar 

  • Pickerell, M. D, and Sawers, R., 1988, Pregnancy after renal transplantation: Severe intrauterine growth retardation during treatment with cyclosporine A, Br. Med. J. 296:825.

    Article  Google Scholar 

  • Pinals, R. S., 1986, Sulfasalazine in the rheumatic diseases: An old agent reborn, Postgrad. Adv. Rheumatol 2:3–12.

    Google Scholar 

  • Pizzuto, J., Aviles, A., Noriega, L., Niz, J., Morales, M., and Romero, E., 1980, Treatment of acute leukemia during pregnancy: Presentation of nine cases, Cancer Treat. Rep. 64:679–683.

    PubMed  CAS  Google Scholar 

  • Popert, A. J., 1962, Pregnancy and adrenocortical hormones, Br. Med. J. 1:967–972.

    Article  PubMed  CAS  Google Scholar 

  • Price, H. V, Salaman, J. R., Laurence, K. M., and Langmaid, H., 1976, Immunosuppressive drugs and the foetus, Transplantation 21:294–298.

    Article  PubMed  CAS  Google Scholar 

  • Pujals, J. M., Figueras, G., Puig, J. M., Lloveras, J., Aubia, J., Masramon, J., 1989, Osseous malformation in baby born to woman on cyclosporine, Lancet 1:667.

    Article  PubMed  CAS  Google Scholar 

  • Registration Committee of the European Dialysis and Transplant Association, 1980, Successful pregnancies in women treated by dialysis and kidney transplantation, Br. Obstet. Gynaecol 87:839–845.

    Article  Google Scholar 

  • Reinisch, J. M., and Simon, N. G., 1978, Prenatal exposure to prednisone in humans and animals retards intrauterine growth, Science 202:436–438.

    Article  PubMed  CAS  Google Scholar 

  • Rocker, I., and Henderson, W. J., 1976, Transfer of gold from mother to fetus, Lancet 2:1246.

    Article  PubMed  CAS  Google Scholar 

  • Rogers, J. G., Anderson, R., Chow, C. W., Gillam, G. L., and Marman, L., 1980, Possible teratogenic effects of gold, Aust. Paediatr. J. 16:194–195.

    PubMed  CAS  Google Scholar 

  • Rooney, T. W., Lorber, A., Veng-Pedersen, P., Herman, R. A., Meehand, R., Hade, J., Hade, A., and Furst, D. E., 1987, Gold pharmacokinetics in breast milk and serum of a lactating woman, J. Rheumatol. 14:1120–1122.

    PubMed  CAS  Google Scholar 

  • Rosenkrantz, J. G., Githens, J. H., Cox, S. M., and Kellum, D. L., 1967, Azathioprine and pregnancy, Am. J. Obstet. Gynecol 97:387–394.

    PubMed  CAS  Google Scholar 

  • Ross, J. B., and Garatsos, S., 1974, Absence of chloroquine-induced ototoxicity in a fetus, Arch. Dermatol 109:573.

    Article  PubMed  CAS  Google Scholar 

  • Rudolph, J. E., Schweizer, R. T., and Bartus, S. A., 1979, Pregnancy in renal transplant patients, Transplantation 27:26–29.

    Article  PubMed  CAS  Google Scholar 

  • Rustin, G. J. S., Booth, M., Dent, J., Salt, S., Rustin, F., Bagshawe, K. D, 1984, Pregnancy after cytotoxic chemotherapy for gestational trophoblastic tumours, Br. Med. J. 288:103–106.

    Article  CAS  Google Scholar 

  • Saarikoski, S., and Seppala, M., 1973, Immunosuppression during pregnancy: Transmission of azathioprine and its metabolites from the mother to the fetus, Am. J. Obstet. Gynecol 115:1100–1106.

    PubMed  CAS  Google Scholar 

  • Sargraves, R., Kaiser, D., and Sharpe, G. L., 1981, Prednisone and prednisolone concentrations in the milk of a lactating mother, Drug Intett. Clin. Pharm. 15:484.

    Google Scholar 

  • Schatz, M., Patterson, R., Zeitz, S., O’Rourke, J., and Malam, H., 1975, Corticosteroid therapy for the pregnant asthmatic patient, J. Am. Med. Assoc. 233:804–807.

    Article  CAS  Google Scholar 

  • Scheinberg, H., and Sternlieb, L., 1975, Pregnancy in penicillamine treated patients with Wilson’s disease, N. Engl. J. Med. 293:1300–1302.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, P. L., Sims, M. E., Strassner, H. T., Paul, R. H., Mueller, E., and McCarth, D., 1984, Effect of antepartum glucocorti-coid administration upon neonatal respiratory distress syndrome and perinatal infection, Am. J. Obstet. Gynecol. 178: 178–186.

    Google Scholar 

  • Serment, H., Charpin, J., Tessier, G., and Felce, A., 1968, Corticothérapie et grossesse, Bull. Féd. Soc. Gynécol. Obstét. Franc. 20:159–161.

    Google Scholar 

  • Sharon, E., Jones, J., Diamond, H., and Kaplan, D., 1974, Pregnancy and azathioprine in systemic lupus erythematosus, Am. J. Obstet. Gynecol. 118:25–28.

    PubMed  CAS  Google Scholar 

  • Shotton, D, and Monie, I. W., 1963, Possible teratogenic effect ofchlorambucil on a human fetus, J. Am. Med. Assoc. 186:74–75.

    Article  CAS  Google Scholar 

  • Sidhu, R. K., 1983, Corticosteroids in pregnancy, in: Drugs and Pregnancy. Human Teratogenesis and Related Problems (D. F. Hawkins, ed.), Churchill Livingstone, Edinburgh, pp. 116–127.

    Google Scholar 

  • Sieber, S. M., and Adamson, R. H., 1975, Toxicity of antineoplastic agents in man: Chromosomal aberrations, antifertility effects, congenital malformations, and carcinogenic potential, Adv. Cancer Res. 22:57–155.

    Article  PubMed  CAS  Google Scholar 

  • Soares, R., Pauline, E., and Pereina, J. P., 1959, Concentration and elimination of chloroquin by the placental circulation and milk in patients receiving chloroquin salt, Bull. Trop. Dis. 56:412.

    Google Scholar 

  • Solomon, L., Abrams, G., Dinner, M., and Berman, L., 1977, Neonatal abnormalities associated with D-penicillamine treatment during pregnancy, N. Engl. J. Med. 296:54–55.

    Article  PubMed  CAS  Google Scholar 

  • Steege, J. F., and Caldwell, D. S., 1980, Renal agenesis after first trimester exposure to chlorambucil, South. Med. J. 73:1414–1415.

    Article  PubMed  CAS  Google Scholar 

  • Suhonen, R., 1983, Hydroxychloroquine administration in pregnancy, Arch. Dermatol. 119:185–186.

    Article  PubMed  CAS  Google Scholar 

  • Tarp, U., and Graudal, H., 1985, A follow-up study of children exposed to gold compounds in utero, Arthritis Rheum. 28:235–236.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, J., and Conklin, K. A., 1983, Anesthetic management of a pregnant patient with scleroderma, Anesthesiology 59: 69–71.

    Article  PubMed  CAS  Google Scholar 

  • Toledo, T. M., Harper, R. C., and Moser, R. H., 1971, Fetal effects during cyclophosphamide and irradiation therapy, Ann. Intern. Med. 74:87–91.

    Article  PubMed  CAS  Google Scholar 

  • Tozman, E. C. S., and Gottlieb, N. L., 1987, Adverse reactions with oral and parenteral gold preparations, Med. Toxicol. 2:177–189.

    Article  PubMed  CAS  Google Scholar 

  • Ullberg, S., Lindquist, N. J., and Sjøstrand, S. E., 1970, Accumulation of chorioretinotoxic drugs in the fetal eye, Nature 227:1257–1258.

    Article  PubMed  CAS  Google Scholar 

  • Varghese, Z., Lui, S. F., Fernando, O. N., Sweny, P., and Moorhead, J. E., 1988, Pregnancy after renal transplantation. Br. Med. J. 296:1400–1401.

    Article  Google Scholar 

  • Varner, M. W., Meehan, R. T., Syrop, C. H., Strottmann, M. P., and Goplerud, C. P., 1983, Pregnancy in patients with systemic lupus erythematosus, Am. J. Obstet. Gynecol 145:1025–1040.

    PubMed  CAS  Google Scholar 

  • Waiden, P. A. M., and Bagshawe, K. D., 1979, Pregnancies after chemotherapy for gestational trophoblast tumours, Lancet 2:1241.

    Google Scholar 

  • Warrell, D. W., and Taylor, R., 1968, Outcome for the fetus of mothers receiving prednisolone during pregnancy, Lancet 1:117–118.

    Article  PubMed  CAS  Google Scholar 

  • Wiernik, P. H., and Duncan, J. H., 1971, Cyclophosphamide in human milk, Lancet 1:912.

    Article  PubMed  CAS  Google Scholar 

  • Williams, P. E., Brons, I. G. M., Evans, D. B., Robinson, R. E., and Calne, R. Y., 1988, Pregnancy after renal transplantation, Br. Med. J. 296:1400.

    Article  Google Scholar 

  • Williamson, R. A., and Karp, L., 1981, Azathioprine teratogenicity: Review of the literature and case report, Obstet. Gynecol. 58:247–250.

    PubMed  CAS  Google Scholar 

  • Willoughby, C. P., and Truelove, S. C., 1980, Ulcerative colitis and pregnancy, Gut 21:469–474.

    Article  PubMed  CAS  Google Scholar 

  • Wolfe, M. S., and Cordero, J. E., 1985, Safety of chloroquine in chemosuppression of malaria during pregnancy, Br. Med. J. 290:1466–1467.

    Article  CAS  Google Scholar 

  • Ziegenhagen, D. J., Crombach, G., Dieckman, M., Zehntner, E., Wienand, P., and Baldamus, C. A., 1988, Schwangerschaft unter Ciclosporin-Medikation nach Nierentransplantation, Dtsch. Med. Wschr. 113:260–263.

    Article  PubMed  CAS  Google Scholar 

  • Zulman, J. I., Talal, N., Hoffman, C. S., and Epstein, W. V, 1980, Problems associated with the management of pregnancies in patients with systemic lupus erythematosus, J. Rheumatol 7:37–49.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, University Hospital of Trondheim, 7006, Trondheim, Norway

    Monika Østensen

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  1. Monika Østensen
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Editors and Affiliations

  1. Department of Clinical Pharmacology, The National Hospital, University of Oslo, N-0027, Oslo 1, Norway

    Hans Erik Rugstad

  2. Institute of Clinical Biochemistry, The National Hospital, University of Oslo, 0027, Oslo 1, Norway

    Liv Endresen

  3. Oslo Sanitetsforening Rheumatism Hospital, N-0172, Oslo 1, Norway

    Øystein Førre

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© 1992 Springer Science+Business Media New York

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Østensen, M. (1992). Immunopharmacological Treatment during Pregnancy and Lactation. In: Rugstad, H.E., Endresen, L., Førre, Ø. (eds) Immunopharmacology in Autoimmune Diseases and Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1167-4_19

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  • DOI: https://doi.org/10.1007/978-1-4899-1167-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1169-8

  • Online ISBN: 978-1-4899-1167-4

  • eBook Packages: Springer Book Archive

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