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Platelet-Activating Factor and Related Compounds

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Mass Spectrometry

Part of the book series: Modern Analytical Chemistry ((MOAC))

Abstract

Platelet-activating factor (PAF) was discovered in 1972 in relation to allergic reaction as a fluid mediator released from basophils (1), and its structure was determined in 1980 as l-alkyl(octadecyl/hexadecyl)-2-acetyl-sn-glycero-3-phosphocholine (2) (Fig. 9.1). Now PAF is known as a chemical mediator of allergic and inflammatory processes and is thought not to be a constituent of animal tissues but to be newly generated from inflammatory cells in response to a variety of stimuli. PAF has a variety of biological activities such as platelet activation, neutrophil activation, increasing vascular permeability, hypotension, etc. and has the strongest agonist action (10 pM) for platelet aggregation. The name, platelet-activating factor, is based on this biological activity and not on its chemical nature. On the other hand, PAF has recently being found in normal animal tissues without any exogenous or inflammatory stimuli, and its level is variable under physiological conditions (3).

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  1. Department of Medical Chemistry, Kansai Medical University, Moriguchi, Osaka 570, Japan

    Kunihiko Saito

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  1. Departments of Neurology and Biochemistry, The University of Tennessee, Memphis, Memphis, Tennessee, USA

    Dominic M. Desiderio

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Saito, K. (1992). Platelet-Activating Factor and Related Compounds. In: Desiderio, D.M. (eds) Mass Spectrometry. Modern Analytical Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1173-5_9

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  • DOI: https://doi.org/10.1007/978-1-4899-1173-5_9

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