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Biochemistry and Pathophysiology of the Molecular Forms of Cholinesterases

  • Chapter
Immunological Aspects

Part of the book series: Subcellular Biochemistry ((SCBI,volume 12))

Abstract

Acetylcholinesterase (acetylcholine acetylhydrolase, AChE: EC 3.1.1.7) and butyrylcholinesterase (acylcholine acylhydrolase, BuChE: EC 3.1.1.8) both possess the capacity to hydrolyze choline esters, although the latter accepts a much wider variety of substrates. These two enzymes are found in a large number of excitable and nonexcitable tissues in most species, including humans (for review see Silver, 1974). The two types of ChE (generic abbreviation for any Cholinesterase) are readily distinguished not only by their substrate specificity but also by their response to selective inhibitors.

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Abbreviations

AChE:

acetylcholinesterase

AD:

Alzheimer’s disease

ALS:

amyotrophic lateral sclerosis

BuChE:

butyrylcholinesterase

cDNA:

complementary DNA

ChAT:

choline acetyltransferase

ChE:

Cholinesterase

CSF:

cerebrospinal fluid

EDL:

extensor digitorum longus

FACS:

fluorescence-activated cell sorter

McAb:

monoclonal antibody

mdg:

muscular dysgenesis

med:

motor endplate disease

NTD:

neural tube defects

PNH:

paroxysmal nocturnal hemoglobinuria

PTA:

phenyltrimethylammonium

RBC:

red blood cell

SCG:

superior cervical ganglion.

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Authors and Affiliations

  1. Central Research Laboratory, Medical University, H-6720, Szeged, Hungary

    Zoltán Rakonczay

  2. Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, 55905, USA

    Stephen Brimijoin

Authors
  1. Zoltán Rakonczay
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  2. Stephen Brimijoin
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  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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© 1988 Springer Science+Business Media New York

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Rakonczay, Z., Brimijoin, S. (1988). Biochemistry and Pathophysiology of the Molecular Forms of Cholinesterases. In: Harris, J.R. (eds) Immunological Aspects. Subcellular Biochemistry, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1681-5_10

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  • DOI: https://doi.org/10.1007/978-1-4899-1681-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1683-9

  • Online ISBN: 978-1-4899-1681-5

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