Abstract
An increase in thromboxane A2 (TXA2) and a decrease in prostacycline (PGI2), which are the metabolites of arachidonic acid, have been reported in patients with lupus nephritis1, 2. The renal prostaglandin system locally modulates cortical and medullary function, renal blood flow, glomerular filtration rate, renin release, sodium and water excretion3. We therefore undertook the present study to evaluate the abnormalities of prostanoid metabolism, which may adversely affect the renal pathophysiology, in an effort to clarify the pathological significance of these prostanoids in lupus nephritis, using SLE patients without nephropathy and healthy controls.
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References
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Yoshida, T., Kameda, H., Masashi, A., Homma, M., Ikeda, Y. (1997). Improvement of Renal Function with Selective Thromboxane A2 Synthetase Inhibitor, DP-1904 in Lupus Nephritis. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_23
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_23
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