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Fundamental Studies of Collision-Induced Dissociation of Ions

  • Chapter
Experimental Mass Spectrometry

Part of the book series: Topics in Mass Spectrometry ((STMS,volume 1))

Abstract

Collision-induced dissociation (CID) [also called collision-activated dissociation (CAD), tandem mass spectrometry, or MS/MS] of ions in a mass spectrometer plays an increasingly significant role in ion structure determination and analysis of complex mixtures.(1,2) Improvement in MS/MS techniques has been a significant driving force in mass spectrometric instrumental development. The CID has attained even greater importance with the advent of fast atom bombardment,(3) laser desorption,(4) and electrospray(5) techniques for generating ions from large, nonvolatile molecules. These techniques usually produce (quasi-and multi-charged) molecular ions with very little fragmentation. Collisional activation of these “molecular” ions and subsequent dissociation to various fragment ions provides structural information about these “molecular ion moities” required for identification and characterization. A few closely related methods, such as angle-resolved(6) and energy-resolved(7) mass spectrometry, surface-induced,(8) and photon-inducedt(9) dissociations have also been developed and succesfully applied in the past decade. Although it is a well-established method with many important applications to chemical analysis, CID remains an active research area in mass spectrometry with many nuances being actively explored.

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Authors and Affiliations

  1. Departments of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, 19716, USA

    Anil K. Shukla & Jean H. Futrell

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  1. Anil K. Shukla
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  2. Jean H. Futrell
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  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    David H. Russell

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Shukla, A.K., Futrell, J.H. (1994). Fundamental Studies of Collision-Induced Dissociation of Ions. In: Russell, D.H. (eds) Experimental Mass Spectrometry. Topics in Mass Spectrometry, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2569-5_3

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  • DOI: https://doi.org/10.1007/978-1-4899-2569-5_3

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