Abstract
The last decade has seen growing concern over the use of medication in the elderly. Many drugs, including some antidepressants (nomifensine and zimeldine), have been introduced only to be withdrawn shortly afterwards because of side-effects. Although in the case of these antidepressants aged-related changes in pharmacokinetics were not the reason for their withdrawal, it has become clear that with increasing years the body’s ability to handle drugs declines and this has important implications both for therapeutic efficacy and for side-effects.
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Crome, P., Dawling, S. (1989). Pharmacokinetics of tricyclic and related antidepressants. In: Ghose, K. (eds) Antidepressants for Elderly People. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3436-9_8
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