Abstract
Swedish scientists have reported associations between dioxin exposure and several cancers, including malignant lymphomas,1 nasal cancers,2 and stomach cancers.3 However, none of these associations has attracted so much attention as the Swedish reports4 mentioned earlier that dioxin exposure of forestry workers caused unexpectedly high numbers of a group of relatively rare tumors, soft tissue sarcomas.* Since these reports were published, nearly all investigations of possible associations between dioxin and cancer have emphasized the possible link between the chemical and soft tissue sarcomas. Little is known about these tumors or about their causes, which may in part explain why the press and some scientists have drawn attention to the possible link. Since dioxin remains a mystery in many ways, one may not need a vivid imagination to see why it is often invoked to explain an even more mysterious form of cancer. In any case, the suggested association affords scientists the opportunity to learn more about these tumors as well as dioxin’s carcinogenicity.
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References
Hardell, L. Relation of soft tissue sarcoma, malignant lymphoma and colon cancer to phenoxy acids, chlorophenols and other agents. Scandinavian J. Work Environmental Health 7:119–130. 1981;
Hardell, L., M. Eriksson, P. Lenner, et al. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: A case-control study. British J. Cancer 43:169–176. 1981.
Hardell, L., B. Johansson, and O. Axelson. Epidemiological study of nasal and nasopharyngeal cancer and their relation to phenoxy acid or chlo-rophenol exposure. British J. Industrial Medicine 3:247–257. 1982.
Axelson, O., L. Sundell, K. Andersson, et al. An updated epidemiologic investigation on Swedish railroad workers. Scandinavian J. Work Environmental Health 6:73–79. 1980.
Hardell, L., and A. Sandstrom. Case control study: Soft tissue sarcomas and exposure to phenoxyacetic acids and chlorophenols. British J. Cancer 39:711–717. 1979;
Eriksson, M., L. Hardell, N. O. Berg, et al. Soft tissue sarcomas and exposure to chemical substances: A case-referent study. British J. Industrial Med. 38:27–33. 1981;
Hardell, L., and M. Eriksson. Soft tissue sarcomas, phenoxy herbicides, and chlorinated phenols. Lancet 2:250. 1981.
Hajdu, S. I. Classification and pathological diagnosis of soft tissue sarcomas. In: Public Health Risks of the Dioxins, ed. Lowrance, W. W. (William Kaufman: Los Altos, California, 1984). pp. 173–186.
Percy, C., E. Stanek, and L. Gloeckler. Accuracy of cancer death certificates and its effect on cancer mortality statistics. American J. Public Health 71:242–250. 1981.
Cited in Council on Scientific Affairs. The Health Effects of “Agent Orange” and Poly chlorinated Dioxin Contaminants: An Update, 1984. Typescript (Chicago: American Medical Association, 1984).
Hardell, L., N. O. Bengtsson, U. Jonsson, et al. Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria—an epidemiological investigation. British J. Cancer 50:389–397. 1984.
Cook, R. R., J. C. Townsend, M. G. Ott, et al. Mortality experience of employees exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). J. Occupational Med. 22:530–532. 1980;
Ott, M. G., B. B. Holder, and B. S. Olson. A mortality analysis of employees engaged in the manufacture of 2, 4, 5-trichlorophenoxyacetic acid. J. Occupational Med. 22:47–50. 1980;
Zack, J. A., and R. R. Suskind. The mortality experience of workers exposed to tetrachlorodibenzodioxin in a trichlorophenol process accident. J. Occupational Med. 22:11–14. 1980;
Zack, J. A., and W. R. Gaffey. A mortality study of workers employed at the Monsanto Company plant in Nitro, West Virginia. In: Human and Environmental Risks of Chlorinated Dioxins and Related Compounds, eds Tucker, R. E., A. L. Young, and A. P. Gray (Plenum Press: New York. 1983). pp. 575–591.
Hardell, L., and O. Axelson. Phenoxyherbicides and other pesticides in the etiology of cancer: Some comments on the Swedish experience. Paper presented at the University of California, San Francisco, December 7–8, 1984.
Eklund, G. Does occupational exposure to chemical pesticides increase the cancer risk? Weed and Plant Protection Conferences. (Swedish University of Agricultural Sciences Research Information Center: Uppsala. 1983). pp. 6–12. (Translated from the Swedish.)
Riihimaki, V., S. Asp, and S. Hernberg. Mortality of 2, 4-dichlorophenox-yacetic acid and 2, 4, 5-trichlorophenoxyacetic acid herbicide applicators in Finland. First report on an ongoing prospective study. Scandanavian J. Work Environmental Health 8:37–42. 1982.
Smith, A. H., D. O. Fisher, H. J. Giles, et al. The New Zealand soft tissue sarcoma case-control study: Interview findings concerning phenoxyacetic acid exposure. Chemosphere 12:565–571. 1983.
See Chapter 4.
Cook, R. R. Soft tissue sarcomas: Clues and caution. In: Human and Environmental Risks of Chlorinated Dioxins and Related Compounds, eds. Tucker, R. E., A. L. Young, and A. P. Gray (New York: Plenum Press, 1983). pp. 613–618.
Hajdu, 1984.5
Honchar, P. A. and W. E. Halperin. 2, 4, 5-trichlorophenol and soft tissue sarcoma. Lancet 1:268–269. 1981.
Office of Technology Assessment. Preventing Illness and Injury in the Workplace. (Washington: Government Printing Office, 1985).
Hajdu, 1984.5
Smith, A. H., N. E. Pearce, D. O. Fisher, et al. Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. J. Natl. Cancer Institute 73:1111–1117. 1984.
Reference to studies in Hardell and Axelson, 1984.9
Hardell and Axelson, 1984.9
See Chapter 12.
See the Appendix.
Hardell and Axelson, 1984.9
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© 1986 Michael Gough
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Gough, M. (1986). Dioxin and Specific Cancers. In: Dioxin, Agent Orange. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6130-3_13
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