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Role of MicroRNAs in Stem Cell Regulation and Tumorigenesis in Drosophila

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MicroRNA in Development and in the Progression of Cancer

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that modulate the expression of target mRNA. They are involved in many biological processes such as developmental timing, differentiation, cell death, immune response, stem cell behavior, and cancer. Growing evidence suggests that miRNAs play vital roles in regulating several aspects of stem cell biology in Drosophila including cell division, self-renewal, and differentiation. In recent years, miRNAs have emerged as collaborating factors that promote the activity of oncogenes in tumor development. Here, we present a brief overview on the role of miRNAs in the regulation of stem cell behavior and tumorigenesis in Drosophila.

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Acknowledgements

This research was supported by the Intramural Research Program, National Cancer Institute of the National Institutes of Health. Lyric Forney is supported by Werner H. Kirsten Student Intern Program (WHK SIP) of National Cancer Institute at Frederick.

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Authors and Affiliations

  1. Mouse Cancer Genetics Program, and Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, 21702, Frederick, MD, USA

    Stephanie Rager, Brian Chan, Lyric Forney & Shree Ram Singh

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  1. Stephanie Rager
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  2. Brian Chan
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  3. Lyric Forney
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  4. Shree Ram Singh
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Correspondence to Shree Ram Singh .

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Editors and Affiliations

  1. National Cancer Institute Mouse Cancer Genetics Program, Frederick, Maryland, USA

    Shree Ram Singh

  2. UMDNJ-NJ Medical School, Newark, New Jersey, USA

    Pranela Rameshwar

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Rager, S., Chan, B., Forney, L., Singh, S. (2014). Role of MicroRNAs in Stem Cell Regulation and Tumorigenesis in Drosophila . In: Singh, S., Rameshwar, P. (eds) MicroRNA in Development and in the Progression of Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8065-6_4

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