Abstract
The desire to provide more opportunities through living donor transplantation has led the field to seek solutions to incompatible donor and recipient pairs. Initial interest in desensitization protocols yielded graft outcomes similar to those seen with deceased donor transplants thereby supporting greater efforts in acquiring pairs with a negative crossmatch and the absence of donor-specific antibody. Through paired kidney exchange, individuals elect to donate their kidney to an unintended recipient following the demonstration of compatibility with the expectation that their intended recipient would, likewise, receive a compatible organ. Often with the aid of complex and multifunctional computer matching programs, PKE programs have expanded from individual centers to nationwide programs involving programs across multiple time zones. From simple two- and three-way simultaneous pairs to both closed and open chains involving a nondirected and a bridge donor, the potential for increasing the number of recipients of living donor organs is seemingly endless. Current efforts in regulating the safety and quality of PKE programs have received much national and media attention.
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Verbesey, J.E., Cooper, M. (2014). Simultaneous Paired Kidney Exchange. In: Weir, M., Lerma, E. (eds) Kidney Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0342-9_6
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DOI: https://doi.org/10.1007/978-1-4939-0342-9_6
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