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Translational Studies of A20 in Atherosclerosis and Cardiovascular Disease

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The Multiple Therapeutic Targets of A20

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 809))

Abstract

Cardiovascular disease (CVD) is the biggest killer in the Western World despite significant advances in understanding its molecular underpinnings. Chronic inflammation, the classical hallmark of atherogenesis is thought to play a key pathogenic role in the development of atherosclerotic lesions from initiation of fatty streaks to plaque rupture. Over-representation of mostly pro-inflammatory nuclear factor kappa B (NF-κB) target genes within atherosclerotic lesions has led to the common-held belief that excessive NF-κB activity promotes and aggravates atherogenesis. However, mouse models lacking various proteins involved in NF-κB signaling have often resulted in conflicting findings, fueling additional investigations to uncover the molecular involvement ofNF-κB and its target genes in atherogenesis. In this chapter we will review the role of the NF-κB-regulated, yet potent NF-κB inhibitory and anti-inflammatory gene A20/TNFAIP3 in atherogenesis, and highlight the potential use of its atheroprotective properties for the prevention and treatment of cardiovascular diseases.

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Authors and Affiliations

  1. Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Fiona C. McGillicuddy, Samira Farouk & Muredach P. Reilly

  2. Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research and the Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Herwig P. Moll, Scott M. Damrauer & Christiane Ferran

  3. Division of Vascular Surgery and Endovascular Therapy, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA

    Scott M. Damrauer

  4. Nutrigenomics Research Group, UCD Conway Institute, School of Public Health & Population Science, University College Dublin, Dublin, Ireland

    Fiona C. McGillicuddy

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  1. Fiona C. McGillicuddy
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  2. Herwig P. Moll
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  3. Samira Farouk
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  4. Scott M. Damrauer
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  5. Christiane Ferran
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  6. Muredach P. Reilly
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Correspondence to Fiona C. McGillicuddy .

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Editors and Affiliations

  1. Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, Boston, Massachusetts, USA

    Christiane Ferran MD, PhD

  2. The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Christiane Ferran MD, PhD

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McGillicuddy, F.C., Moll, H.P., Farouk, S., Damrauer, S.M., Ferran, C., Reilly, M.P. (2014). Translational Studies of A20 in Atherosclerosis and Cardiovascular Disease. In: Ferran, C. (eds) The Multiple Therapeutic Targets of A20. Advances in Experimental Medicine and Biology, vol 809. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0398-6_6

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