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Acetylation in the Control of Mitochondrial Metabolism and Integrity

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Cardiac Energy Metabolism in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 11))

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Abstract

Acetylation, as a post-translational modification is increasingly recognized as a nutrient-level dependent modulatory event in the control of cellular function. Non-enzymatic and enzymatic mechanisms appear to function in facilitating this modification of protein lysine residues. The functional role of protein acetylation was originally linked to lifespan regulation in simple organisms under the control of sirtuin deacetylase enzymes. In higher organisms this regulatory system is evolved to modulate in diverse cellular functions and is operational in multiple subcellular compartments. In this chapter the role of acetylation and its regulatory control is explored in the context of the control of mitochondrial integrity and metabolic functioning. Moreover, the concept that protein acetylation may function as a nutrient sensor to ‘fine-tune’ mitochondrial function as an underpinning of cardiac pathology will be explored.

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Authors and Affiliations

  1. Cardiovascular and Pulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bldg 10/CRC 5-3150, Bethesda, MD, 20892, USA

    Michael N. Sack

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Correspondence to Michael N. Sack .

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Editors and Affiliations

  1. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

    Gary D. Lopaschuk

  2. University of Manitoba, Institute of Cardiovascular Sciences, St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Sack, M.N. (2014). Acetylation in the Control of Mitochondrial Metabolism and Integrity. In: Lopaschuk, G., Dhalla, N. (eds) Cardiac Energy Metabolism in Health and Disease. Advances in Biochemistry in Health and Disease, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1227-8_8

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