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Opioids and Substance Abuse

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Substance Abuse

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Abstract

Opioids are a class of medications that have been associated with potent analgesia. Used for thousands of years as effective agents to treat malignant and nonmalignant pain, opioids evolved from simple extracts and alkaloids to potent synthetic formulations employed to treat acute and chronic pain. With extending their role into treating the chronic pain syndromes, controversies arise on the proper indications of those agents questioning the balance between effective pain treatments and the liability for abuse. This chapter will explore the use of opioids and their potential for abuse as well as regulatory mechanisms to limit liability of their use.

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References

  1. Corbett AD, Henderson HG, McKnight AT, et al. 75 years of opioid research: the exciting but vain quest for the Holy Grail. Br J Pharmacol. 2006;146:S152–62.

    Google Scholar 

  2. Mogil JS, Grisel JE. Transgenic studies of pain. Pain. 1998;77:107–28.

    Article  CAS  PubMed  Google Scholar 

  3. McDonald J, Lambert DG. Opioid receptors. Contin Educ Anaesth Crit Care Pain. 2005;5(1):22–5.

    Article  Google Scholar 

  4. Zacny J, Bigelow G, Comptom P, et al. College on problems of drug dependence taskforce on prescription opioid non-medical use and abuse: position statement. Drug Alcohol Depend. 2003;69:215–32.

    Article  PubMed  Google Scholar 

  5. Weissman DE, Haddox JD. Opioid pseudoaddiction—an iatrogenic syndrome. Pain. 1989;36(3):363–6.

    Article  CAS  PubMed  Google Scholar 

  6. Campbell J. MD Presidential Address, American Pain Society November 11, 1996. http://www.va.gov/;ainmangement/doc/toolkit.pdf. Accessed 26 July 2013.

  7. Paulozzi LJ, et al. Vital signs: overdoses of prescription opioid pain relievers—United States, 1999–2008. Morb Mortal Wkly Rep. 2011;60(43):1487–92.

    Google Scholar 

  8. Manchikanti L, Abdil S, Alturi S, et al. American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: part I—evidence assessment. Pain Physician. 2012;15(3 Suppl):S1–65.

    PubMed  Google Scholar 

  9. Grattan A, Sullivan MD, Saunders KW, et al. Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse. Ann Fam Med. 2012;10(4):304–11.

    Article  PubMed Central  PubMed  Google Scholar 

  10. http://www.cdc.gov/vitalsigns/painkilleroverdoses/. Accessed 26 July 2013.

  11. Substance Abuse and Mental Health Services Administration. Results from the 2011 national survey on drug use and health: summary of national findings. NSDUH Series H-44, HHS Publication No. (SMA) 12-4713. Rockville: Substance Abuse and Mental Health Services Administration; 2012.

    Google Scholar 

  12. Substance Abuse and Mental Health Services Administration. Office of applied studies: treatment episode data set (TEDS). http://wwwdasis.samhsa.gov/webt/NewMapv1.htm

  13. Cleland et al. Substance abuse treatment, prevention, and policy 2011, 6:11. http://www.substanceabusepolicy.com/content/6/1/11. Accessed 26 July 2013.

  14. Butler SF, Black RA, Cassidy TA, Dailey TM, Budman SH. Abuse risks and routes of administration of different prescription opioid compounts and formulations. Harm Reduct J. 2011;8.

    Google Scholar 

  15. Swedlow A, Ireland J, Johnson G. Prescribing patterns of schedule II opioids in California workers’ compensation. California Workers Compensation Institute. www.cwci.org. Accessed 25 June 2013.

  16. Birnbaum HG, White AG, Schiller M, et al. Societal costs of prescription opioid abuse, dependence, and misuse in the United States. Pain Med. 2011;12:656–67.

    Article  Google Scholar 

  17. Coalition Against Insurance Fraud. Prescription for peril: how insurance fraud finances theft and abuse of addictive prescription drugs. Washington, DC: Coalition Against Insurance Fraud; 2007. http://www.insurancefraud.org/downloads/drugDiversion.pdf. Accessed 26 Sept 2011.

  18. Prescription drugs: abuse and addiction. NIH Publication Number 11-4881. July 2001, Revised October 2011. www.drugabuse.gov/sites/default/files/rrprescription.pdf. Accessed 26 July 2013.

  19. Substance Abuse and Mental Health Services Administration. Highlights of the 2009 Drug Abuse Warning Network (DAWN) findings on drug-related emergency department visits. The DAWN Report. Rockville: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration; 2010. http://oas.samhsa.gov/2k10/dawn034/edhighlights. Accessed 3 Oct 2011.

  20. Alexander GA, Kruszewski SP, Webster DW. Rethinking opioid prescribing to protect patient safety and public health. J Am Med Assoc. 2012;308(18):1865–6.

    Article  CAS  Google Scholar 

  21. Centers for Disease Control and Prevention. CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61(39):10–3.

    Google Scholar 

  22. Dunn KM, Saunders KW, Rutter CM, et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med. 2010;152:85–92.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Boudreau D, Von Korff M, Rutter CM, et al. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf. 2009;18:1166–75.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Noble M, Treadwell JR, Tregear SJ, et al. Long-term opioid management for chronic non-cancer pain. Cochrane Database Syst Rev. 2010;(1):CD006605.

    Google Scholar 

  25. Seghal N, Manchikanti L, Smith HS. Prescription opioid abuse in chronic pain: a review of opioid abuse predictors and strategies to curb opioid abuse. Pain Physician. 2012;15:ES67–92.

    Google Scholar 

  26. Rigg KK, Murphy JW. Understanding the etiology of prescription opioid abuse: implications for prevention and treatment. Qual Health Res. 2013;23(7):963–75.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Boscarino JA, Rukstalis M, Hoffman SN, et al. Risk factors for drug dependence among out-patients on opioid therapy in a large US health-care system. Addiction. 2010;105:1776–82.

    Article  PubMed  Google Scholar 

  28. Edlund MJ, Martin BC, Fan M, et al. Risks for opioid abuse and dependence among recipients of chronic opioid therapy: results from the TROUP study. Drug Alcohol Depend. 2010;112:90–8.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Grattan A, Sullivan MD, Saunders KW, et al. Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse. Ann Fam Med. 2012;10(4):304–11.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Spiller H, Lorenz DL, Bailet EJ, et al. Epidemiological trends in abuse and misuse of prescription opioids. J Addict Dis. 2009;28:130–13.

    Article  PubMed  Google Scholar 

  31. Brownstein JS, Green TC, Cassidy TA, et al. Geographic information systems and pharmacoepidemiology: using spatial cluster detection to monitor local patterns of prescription opioid abuse. Pharmacoepidemiol Drug Saf. 2010;19:627–37.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Cicero TJ, Surratt HL, Kurtz S, et al. Patterns of prescription opioid abuse and comorbidity in an aging treatment population. J Subst Abuse Treat. 2013;42:87–94.

    Article  Google Scholar 

  33. Katz C, El-Gabalawy E, Keyes KN, et al. Risk factors for incident nonmedical prescription opioid use and abuse and dependence: results from a longitudinal nationally representative sample. Drug Alcohol Depend. 2013;132.

    Google Scholar 

  34. Manubay JM, Muchow C, Sullivan MA. Prescription drug abuse: epidemiology, regulatory issues, chronic pain management with narcotic analgesics. Prim Care. 2011;38(1):71.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Schneider JP, Matthews M, Jamison R. Abuse-deterrent and tamper-resistant opioid formulations—what is their role in addressing prescription opioid abuse? CNS Drugs. 2010;24(10):805–10.

    Article  CAS  PubMed  Google Scholar 

  36. U.S. Food and Drug Administration. Risk evaluation and mitigation strategies for certain opioid drugs; notice of public hearing. April 20, 2009. http://www.fda.gov/OHRMS/DOCKETS/98fr/E9-8992.pdf

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Authors and Affiliations

  1. Department of Anesthesiology, Center for Advanced Medicine, Western Anesthesia Associates, Pain Management Center, Washington University School of Medicine, 4921 Parkview Place, Suite 14-C, St. Louis, MO, 63110, USA

    Matthew Verne Satterly M.D.

  2. Department of Anesthesia and Critical Care, University of Chicago Medical Center, 5513 South Kimbark Avenue, Chicago, IL, 60637, USA

    Magdalena Anitescu M.D., Ph.D.

Authors
  1. Matthew Verne Satterly M.D.
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  2. Magdalena Anitescu M.D., Ph.D.
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Corresponding author

Correspondence to Magdalena Anitescu M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Louisiana State University Health Sciences Center, Louisiana State University Interim Hospital, and Ochsner Kenner Hospital, Departments of Anesthesiology and Pharmacology, New Orleans, Louisiana, USA

    Alan David Kaye

  2. Department of Anesthesiology, Yale University School of Medicine and Yale-New Haven Hospital, New Haven, Connecticut, USA

    Nalini Vadivelu

  3. Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Richard D. Urman

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Satterly, M.V., Anitescu, M. (2015). Opioids and Substance Abuse. In: Kaye, A., Vadivelu, N., Urman, R. (eds) Substance Abuse. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1951-2_15

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  • DOI: https://doi.org/10.1007/978-1-4939-1951-2_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1950-5

  • Online ISBN: 978-1-4939-1951-2

  • eBook Packages: MedicineMedicine (R0)

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