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Prevention of Conversion of Tumor Dormancy into Proliferative Metastases

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Circulating Tumor Cells

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Late recurrences of cancer are believed to be due to dormant disease that can persist for long periods following apparently successful treatment of a primary tumor. Clinical tumor dormancy thus creates uncertainty for cancer patients and their physicians, who cannot be certain that their cancer will not recur. We have a poor understanding about which individual patients are at risk for cancer recurrence following a period of tumor dormancy. Thus, in spite of the clinical importance of tumor dormancy, much remains to be learned about the mechanisms responsible for induction of, and release from, dormancy. Here we consider the clinical problem of tumor dormancy and discuss evolving ideas of how tumor dormancy and reinitiation of growth may be regulated, both naturally in the body and therapeutically. A better understanding of mechanisms by which dormancy can be regulated may suggest new therapeutic approaches to either eliminate dormant cancer cells or promote the maintenance of dormancy.

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Authors and Affiliations

  1. Laboratory of Tumor Dormancy and Metastasis, Department of Biology and Human Biology, Faculty of Natural Sciences, University of Haifa, Mount Carmel, Haifa, 31905, Israel

    Dalit Barkan Ph.D.

  2. Departments of Oncology, Medical Biophysics and Pathology & Laboratory Medicine, London Regional Cancer Program, London Health Sciences Centre/University of Western Ontario, 790 Commissioners Road East, London, ON, N6A 4L6, Canada

    Ann F. Chambers Ph.D.

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  1. Dalit Barkan Ph.D.
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Correspondence to Dalit Barkan Ph.D. .

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Editors and Affiliations

  1. Jackson Memorial Hospital, University of Miami, Miami, Florida, USA

    Richard J. Cote

  2. University of Miami, Miami, Florida, USA

    Ram H. Datar

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Barkan, D., Chambers, A.F. (2016). Prevention of Conversion of Tumor Dormancy into Proliferative Metastases. In: Cote, R., Datar, R. (eds) Circulating Tumor Cells. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3363-1_7

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  • DOI: https://doi.org/10.1007/978-1-4939-3363-1_7

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