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Antioxidants and Endothelium-Derived Nitric Oxide Action

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Nitric Oxide and the Cardiovascular System

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

In 1980, Furchgott and Zawadzki demonstrated the release of an endothelium-derived relaxing factor in isolated rabbit aorta with exposure to acetylcholine (ACh) (1). This factor has subsequently been identified as nitric oxide (NO·) (2) or a closely related redox form of NO· (3). It is now known that NO· is synthesized enzymatically from L-arginine and O2 by a family of FAD- and FMN-containing enzymes, the nitric oxide synthases (NOSs), that require NADPH and tetrahydrobiopterin (BH4) as cofactors (4). As a class of enzymes, the NOSs appear ubiquitous and have been identified in a number of mammalian cell types and tissues including endothelium (5), epithelium (6), neurons skeletal muscle (8), ventricular myocardium (9), and cytokine-stimulated inflammatory cells (10,11).

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Authors
  1. Annong Huang
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  2. John F. Keaney Jr.
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Editors and Affiliations

  1. Boston University Medical Center, Boston, MA, USA

    Joseph Loscalzo MD, PHD  & Joseph A. Vita MD  & 

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Huang, A., Keaney, J.F. (2000). Antioxidants and Endothelium-Derived Nitric Oxide Action. In: Loscalzo, J., Vita, J.A. (eds) Nitric Oxide and the Cardiovascular System. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-002-5_26

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  • DOI: https://doi.org/10.1007/978-1-59259-002-5_26

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-101-1

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