Abstract
Nitric oxide (NO·) and related chemical species have emerged as ubiquitous cellular messengers. This smallest known mammalian biological signaling molecule plays a crucial role in human physiology. NO· is synthesized by the enzyme nitric oxide synthase (NOS) and can assume several chemical forms, each of which has its own reactive specificity toward cellular targets. The resulting interaction initiates many signaling events in the cell. NO·-induced signal transduction and gene expression influences various physiological events including vasodilation, cytotoxicity, inflammation, and synaptic plasticity.
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Deora, A.A., Lander, H.M. (2000). Regulation of Gene Expression by Nitric Oxide. In: Loscalzo, J., Vita, J.A. (eds) Nitric Oxide and the Cardiovascular System. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-002-5_4
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