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Update on Arachidonic Acid Cascade

Leukotrienes and Lipoxins in Disease Models

  • Chapter
Molecular and Cellular Basis of Inflammation

Part of the book series: Current Inflammation Research ((CIRES))

Abstract

Biomembranes act as barriers to cellular compartments and serve as storage sites for precursors of rapidly generated, structurally diverse lipid-derived mediators (LMs). Cellular responses are accompanied by the rapid remodeling of membrane lipids, by activated lipases, with concomitant generation of bioactive lipids that can serve as both intra- and/or extracellular mediators. To qualify as an LM, the product of these pathways must act in a stereoselective fashion and be generated by cells and tissues in quantities that are commensurate with their potency and range of actions in vivo. The generation and release of extracellular LMs are generally cell-type specific as is the case with individual classes of eicosanoids, whereas the biosynthesis of key intracellular LMs such as diacylglycerol (DAG) or ceramide appear to be ubiquitous in signal transduction. Given the profile of bioactions of individual LMs and the cell types presently known to be involved in their formation, they are held to play essential roles in a wide range of processes involving cell—cell communication, including host defense, inflammation, ischemia-reperfusion, hemostasis, and other vascular events.

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Authors
  1. Jesper Z. Haeggström
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  2. Charles N. Serhan
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Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

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Haeggström, J.Z., Serhan, C.N. (1999). Update on Arachidonic Acid Cascade. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_3

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