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Resistance to Thyroid Hormone

  • Chapter
Diseases of the Thyroid

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Fuller Albright introduced the concept of hormone resistance in the 1940s (1,2). In the ensuing half century, multiple hormone-resistance syndromes were described, including resistance to thyroid hormone (RTH) by Refetoff, DeWind, and DeGroot in 1967 (3). Their patient was a 6-yr-old girl evaluated after a car accident and found to have signs of hypothyroidism (stippled epiphyses, deaf-mutism, delayed bone age, and goiter) in the presence of an increased protein bound iodine (PBI, then used as a surrogate for total T4) concentration. Subsequent investigation found that the patient had normal thyroid hormones (TH) with a normal hormone secretion rate, tissue distribution, fractional turnover, and transport proteins.

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  1. Joshua D. Safer MD
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  1. Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA, USA

    Lewis E. Braverman MD (Chief) (Chief)

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Safer, J.D. (2003). Resistance to Thyroid Hormone. In: Braverman, L.E. (eds) Diseases of the Thyroid. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-352-1_10

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