Abstract
Early diagnosis and treatment of hypothyroidism is the exception rather than the rule. Despite its high prevalence (1–3) and potential consequences, hypothyroidism is typically diagnosed in clinical settings at an advanced and often longstanding stage or is incidentally detected during a wide-ranging evaluation for nonspecific complaints. Even when hypothyroidism should be anticipated, such as in patients who have received neck irradiation (4) or amiodarone therapy (5), its recognition is often delayed. Only in neonates, for whom universal thyroid function testing is mandated in most industrialized societies, is hypothyroidism identified early and treated promptly. Application of the principles of preventive medicine to hypothyroidism has occurred slowly, except in the worldwide efforts to prevent dietary iodine deficiency disorders, including endemic goiter, hypothyroidism, and cretinism (6).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489–499.
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526–534.
Vanderpump MPJ, Tunbridge WMG. The epidemiology of thyroid diseases. In: Braverman LE, Utiger RD, eds. Werner & Ingbar’s The Thyroid: A Fundamental and Clinical Text, 8th ed. Lippincott Williams & Wilkins, Philadelphia, 2000, pp. 467–473.
Hancock SL, Cox RS, McDougall IR. Thyroid diseases after treatment of Hodgkin’s disease. N Engl J Med 1991;325:599–605.
Martino E, Safran M, Aghini-Lombardi F, et al. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med 1984;101:28–34.
Delange F, de Benoist B, Pretell E, Dunn JT. Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid 2001;11:437–447.
Powe NR, Danese M, Ladenson PW. Decision analysis in endocrinology and metabolism. J Clin Endocrinol Metab 1997;26:89–112.
Barbesino G, Chiovato L. The genetics of Hashimoto’s disease. Endocrinol Metab Clin North Am 2000;29:357–374.
Rosenbloom AL, Almonte AS, Brown MR, Fisher DA, Baumbach L, Parks JS. Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene. J Clin Endocrinol Metab 1999;84:50–57.
Hayashizaki Y, Hiraoka Y, Tatsumi K, et al. Deoxyribonucleic acid analyses of five families with familial inherited thyroid stimulating hormone deficiency. J Clin Endocrinol Metab 1990;71:792–796.
Yen PM. Thyrotropin receptor mutations in thyroid diseases. Rev Endocr Metab Disord 2000;1:123–129.
Spiegel AM. Hormone resistance caused by mutations in G proteins and G protein-coupled receptors. J Pediatr Endocrinol Metab 1999;12(suppl 1):303–309.
Pohlenz J, Dumitrescu A, Aumann U, et al. Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene. J Clin Endocrinol Metab 2002;87:336–339.
Targovnik HM, Frechtel GD, Mendive FM, et al. Evidence for the segregation of three different mutated alleles of the thyroglobulin gene in a Brazilian family with congenital goiter and hypothyroidism. Thyroid 1998;8:291–297.
Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie 1999;81:469–476.
Pannain S, Weiss RE, Jackson CE, et al. Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping. J Clin Endocrinol Metab 1999;84:1061–1071.
Kopp P. Pendred’ s syndrome: identification of the genetic defect a century after its recognition. Thyroid 1999;9:65–69.
Delange F. The disorders induced by iodine deficiency. Thyroid. 1994;4:107–128.
Feldt-Rasmussen U. Iodine and cancer. Thyroid 2001;11:483–486.
Wolff J. Physiology and pharmacology of iodized oil in goiter prophylaxis. Medicine (Baltimore) 2001;80:20–36.
Laurberg P, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E, Knudsen PR. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 1998;83:765–769.
Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K. Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 1994 78:393–397.
Allen EM, Braverman LE. The effect of iodine on lymphocytic thyroiditis in the thymectomized buffalo rat. Endocrinology 1990;127:1613–1616.
Rose NR, Rasooly L, Saboori AM, Burek CL. Linking iodine with autoimmune thyroiditis. Environ Health Perspect 1999;107(suppl. 5):749–752.
Tajiri J, Higashi K, Morita M, Umeda T, Sato T. Studies of hypothyroidism in patients with high iodine intake. J Clin Endocrinol Metab 1986;63:412–417.
Fukata S, Kuma K, Sugawara M. Relationship between cigarette smoking and hypothyroidism in patients with Hashimoto’s thyroiditis. J Endocrinol Invest 1996;19:607–612.
Nystrom E, Bengtsson C, Lapidus L, et al. Smoking-a risk factor for hypothyroidism. J Endocrinol Invest 1993;16:129–131.
Muller B, Zulewski H, Huber P, et al. Impaired action of thyroid hormone associated with smoking in women with hypothyroidism. N Engl J Med 1995;333:964–969.
Vestergaard P, Rejnmark L, Weeke J, et al. Smoking as a risk factor for Graves’ disease, toxic nodular goiter, and autoimmune hypothyroidism. Thyroid 2002;12:69–75.
Fukata S, Kuma K, Sugawara M. Relationship between cigarette smoking and hypothyroidism in patients with Hashimoto’s thyroiditis. J Endocrinol Invest 1996;19:607–612.
Colzani R, Fang SL, Alex S, et al. The effect of nicotine on thyroid function in rats. Metabolism 1998;47:154–157.
Utiger RD. Effects of smoking on thyroid. Eur J Endocrinol 1998;138:368–369.
Muller B, Zulewski H, Huber P, et al. Impaired action of thyroid hormone associated with smoking in women with hypothyroidism. N Engl J Med 1995;333:964–969.
Bahn AK, Mills JL, Synder PJ, et al. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med 1980;302:31–33.
Byrne JJ, Carbone JP, Hanson EA. Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl. Endocrinology 1987;121:520–527.
Roberts FP, Wright AL, O’Hagan SA. Hypothyroidism in textile workers. J Soc Occup Med 1990;40:153–156.
Katin MJ, Teehan BP, Sigler MH, Schleifer CR, Gilgere GS. Resorcinol-induced hypothyroidism in a patient on chronic hemodialysis. Ann Intern Med 1977;86:447–449.
Dowsett M, Mehta A, Cantwell BM, Harris AL. Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion. Eur J Cancer 1991;27:846–849.
Koh LK, Greenspan FS, Yeo PP. Interferon-alpha induced thyroid dysfunction: three clinical presentations and a review of the literature. Thyroid 1997;7:891–896.
Robbins J, Schneider AB. Thyroid cancer following exposure to radioactive iodine. Rev Endocr Metab Disord 2000;1:197–203.
Goldsmith JR, Grossman CM, Morton WE, et al. Juvenile hypothyroidism among two populations exposed to radioiodine. Environ Health Perspect 1999;107:303–308.
Becker DV, Braverman LE, Dunn JT, et al. The use of iodine as a thyroidal blocking agent in the event of a reactor accident. Report of the Environmental Hazards Committee of the American Thyroid Association. JAMA 1984;252:659–661.
Order SE, Sleeper AM, Stillwagon GB, Klein JL, Leichner PK. Current status of radioimmunoglobulins in the treatment of human malignancy. Oncology (Huntingt) 1989;3:115–120
Allahabadia A, Daykin J, Sheppard MC, Gough SC, Franklyn JA. Radioiodine treatment of hyperthyroidism-prognostic factors for outcome. J Clin Endocrinol Metab 2001;86:3611–3617.
Jones SJ, Hedley AJ, Curtis B, et al. Do we need thyroid follow-up registers? A cost-effective study. Lancet 1982;1:1229–1233.
Harrison LC, Buckley JD, Martin FI. Use of a computer-based postal questionnaire for the detection of hypothyroidism following radioiodine therapy for thyrotoxicosis. Aust N Z J Med 1977;7:27–32.
Falkenberg M, Nilsson OR, Rosenqvist U. Value of thyroid follow-up registers. Scand J Prim Health Care 1987;5:181–185.
Meyer CM, Ladenson PW, Scharfstein JA, Danese MD, Powe NR. Evaluation of common problems in primary care: effect of physician, practice and financial considerations. J Manag Care 2000;6:457–472.
LaFranchi S. Congenital hypothyroidism: etiologies, diagnosis, and management. Thyroid 1999;9:735–740.
Belin RM, Ladenson PW, Robinson KA, Powe NR. Development and use of evidence-based clinical practice guidelines for thyroid disease. Endocrinol Metab Clin North Am 2002;31:795–817.
Danese MD, Powe NR, Sawin CT, Ladenson PW. Screening for mild thyroid failure at the periodic health examination: a decision and cost-effectiveness analysis. JAMA 1996;276:285–292.
Nicoloff JT, LoPresti JS. Myxedema coma. A form of decompensated hypothyroidism. Endocrinol Metab Clin North Am 1993;22:279–290.
Danese MD, Ladenson PW, Meinert CL, Powe, NR. Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab 2000;85:2993–3001.
Perk M, O’Neill BJ. The effect of thyroid hormone therapy on angiographic coronary artery disease progression. Can J Cardiol 1997;13:273–276.
Ladenson, PW. Problems in the management of hypothyroidism. In: Braverman LE, ed. Diseases of the Thyroid, 2nd ed. Humana, Totowa, NJ, 2002, pp. 161–176.
Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001;344:501–509.
Trence DL, Morley JE, Handwerger BS. Polyglandular autoimmune syndromes. Am J Med 1984;77:107–116.
Ladenson PW, Singer PA, Levy EG, et al. American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med 2000;160:1573–1575. (http://www.thyroid.org/publications/guidelines.html).
Vanderpump, MP, Ahlquist, JA, Franklyn, JA, et al. Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. BMJ 1996;313:539–544. (http://bmj.com/cgi/content/full/313/7056/539).
Spencer CA. National Academy of Clinical Biochemistry laboratory medicine practice guidelines for the diagnosis and monitoring of thyroid disease testing. The American Thyroid Association. (Last updated 9–12-2001. http://www.thyroid.org/resources/professional/nacb_comment.rtf).
Surks MI, Chopra IJ, Mariash CN, et al. American Thyroid Association guidelines for use of laboratory tests in thyroid disorders. JAMA 1990;263:1529–1532.
American Academy of Pediatrics. Newborn screening for congenital hypothyroidism: recommended guidelines. Pediatrics 1993;91:1203–1209.
Commission on Clinical Policies and Research, Working Group on Periodic Health Examinations, AAFP Board of Directors: Periodic Health Examinations: Summary of AAFP Policy Recommendations & Age Charts. American Academy of Family Physicians. (Last updated 2001. http://www.aafp.org/exam/intro.html).
Beaulieu MD. Screening for congenital hypothyroidism. Canadian Task Force on Preventive Health Care. (Last updated 1994. http://www.ctfphc.org/).
U.S. Preventive Services Task Force: Screening for congenital hypothyroidism. In Guide to Clinical Preventive Services, 2nd ed. Williams & Wilkins, Baltimore, 1996, pp 503–507. (http://hstat.nlm.nih.gov/ftrs/directBrowse.pl?collect=cps&dbName=cps&href=CH45).
Helfand M, Redfern C. Screening for thyroid disease: an update. Ann Intern Med 1998;129:141–158. (http://www.acponline.org/journals/annals/15ju198/ppthyroid2.htm).
U.S. Preventive Services Task Force: Screening for thyroid disease. In: Guide to Clinical Preventive Services, 2nd ed. Williams & Wilkins, Baltimore, 1996, pp 209–218. (http:// hstat.nlm.nih.gov)/ftrs/directBrowse.pl?collect=cps&dbName=cps&href=CH20.
Beaulieu MD. Screening for thyroid disorders and thyroid cancer in asymptomatic adults. Canadian Task Force on Preventive Health Care. (Last updated 1994. http://www.ctfphc.org/).
Gharib H, Cobin RH, Dickey RA. Subclinical hypothyroidism during pregnancy: position statement from the American Association of Clinical Endocrinologists. Endocr Pract 1999;5:367–368. (http://www.aace.com)/clin.guidelines/pregnancy.pdf.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ladenson, P.W., Belin, R.M. (2003). Hypothyroidism. In: Bar, R.S. (eds) Early Diagnosis and Treatment of Endocrine Disorders. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-378-1_2
Download citation
DOI: https://doi.org/10.1007/978-1-59259-378-1_2
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61737-414-2
Online ISBN: 978-1-59259-378-1
eBook Packages: Springer Book Archive