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Molecular Basis for Binding Multiple Cytokines by γc

Implications for X-SCID and Impaired γc-Dependent Cytokine Receptor Function

  • Chapter
Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Summary

Mutations in γc, a shared receptor subunit for interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21, lead to profound impairment in T-cell and natural killer (NK) cell development and are responsible for X-linked severe combined immunodeficiency disease (X-SCID). Considerable attention has been paid to how the lack of γc expression and signaling results in failed lymphocyte development. However, γc is also an essential ligand binding subunit for γc-dependent cytokine receptors. Molecular modeling in conjunction with site-directed mutagenesis of γc indicates that a common mechanism is responsible for the ability of γc to bind multiple cytokines. This notion is related to instances in which mutations in the extracytoplasmic region of γc resulted in X-SCID.

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Authors
  1. Ferenc Olosz
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  2. Thomas R. Malek
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Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Giamila Fantuzzi PhD

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© 2003 Springer Science+Business Media New York

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Olosz, F., Malek, T.R. (2003). Molecular Basis for Binding Multiple Cytokines by γc. In: Fantuzzi, G. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-405-4_9

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  • DOI: https://doi.org/10.1007/978-1-59259-405-4_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-415-9

  • Online ISBN: 978-1-59259-405-4

  • eBook Packages: Springer Book Archive

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