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Plasticity of Adult-Derived Pancreatic Stem Cells

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Stem Cells Handbook

Abstract

The pancreas develops from fusion of dorsal and ventral evaginations from the primitive gut. Active notch signaling leads to expression of transcription factors for exocrine cells, and lack of notch to expression of factors for endocrine cells. The islets of Langerhans develop from a pool of undifferentiated precursor cells associated with the ductal epithelium that have the capacity to produce progeny that differentiate into each of the four islet-associated endocrine cells: glucagon producing α-cells, insulin-producing β-cells, somatostatin-producing δ-cells, and pancreatic polypeptide-producing γ-cells. Islets are formed by migration of the islet progenitor cells into the surrounding exocrine tissue associated with angiogenesis to provide a rich arteriolar blood supply. In the adult, the pancreatic ducts contain precursor cells, which are able to self-renew and differentiate into functional islets; exocrine cells; and, under certain conditions, hepatocytes. The isolation, culture, and transplantation of the progeny of these precursor cells for treatment of experimental diabetes are described and prospects for human use are discussed.

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Authors
  1. Ammon B. Peck PhD
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  2. Vijayakumar K. Ramiya PhD
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Editors and Affiliations

  1. Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY, USA

    Stewart Sell MD

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Peck, A.B., Ramiya, V.K. (2004). Plasticity of Adult-Derived Pancreatic Stem Cells. In: Sell, S. (eds) Stem Cells Handbook. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-411-5_37

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  • DOI: https://doi.org/10.1007/978-1-59259-411-5_37

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-367-1

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