Abstract
The pathogenesis of spontaneous systemic lupus erythematosus (SLE) appears to be the outcome of numerous abnormalities of the immune system, including a generalized hyperactivity of T and B cells (1–4). However, autoimmunity in lupus is not global; it is directed mainly against nuclear antigens (5–7). Although autoantibodies that bind DNA play a major role in the development of lupus nephritis, B cells of normal subjects can produce “natural” anti-DNA autoantibodies (8). Furthermore, DNA is only a target antigen and not the primary immunogen, because deliberate immunization with DNA does not lead to SLE (9,10). This chapter describes our studies on the NZB × SWR model, as well as human SLE that have simplified some of these complexities and paradoxes of lupus and are helping to define the primary immunogen(s) that drives the pathogenic autoimmune response in this disease (11).
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References
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Datta, S.K. (1999). Mechanisms of the Pathogenic Autoimmune Response in Lupus. In: Kammer, G.M., Tsokos, G.C. (eds) Lupus. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-703-1_12
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