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Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids

  • Chapter
Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

d-Limonene and perillyl alcohol monoterpenes with low toxicity have cancer-chemopreventive and chemotherapeutic activity against solid cancers and leukemias, which include most of the leading causes of cancer-related death. Monoterpenes are among the numerous and diverse naturally occurring isoprenoids that are synthesized in plants (1). Isoprenoids include monoterpenes (10 carbons), sesquiterpenes (15 carbons), diterpenes (20 carbons), and triterpenes (30 carbons). The monoterpene geraniol and the sesquiterpene farnesol show promise as more potent compounds than d-limonene or perillyl alcohol in vivo, and are in development for clinical cancer prevention. Although many reviews have summarized the anticancer activities of isoprenoids (2-9), this chapter focuses on isoprenoid mechanisms of action and clinical applications for d-limonene, perillyl alcohol, geraniol, and farnesol (Fig. 1).

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Authors
  1. Pamela L. Crowell PhD
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  2. Michael N. Gould PhD
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Editors and Affiliations

  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Crowell, P.L., Gould, M.N. (2004). Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_25

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  • DOI: https://doi.org/10.1007/978-1-59259-767-3_25

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