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192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System

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Molecular Neurosurgery With Targeted Toxins

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Abstract

The anti-p75-immunotoxin 192 immunoglobulin G-saporin (192 IgG-sap) has been instrumental in testing the hypothesis that the integrity of the cortical cholinergic input system is necessary for the mediation of a wide range of attentional functions and capacities (1–10). As discussed elsewhere (11), attentional functions represent a crucial set of cognitive variables that contribute to the efficacy of learning and recalling of declarative information. Thus, impairments in attentional abilities rapidly yield escalating impairments in learning and memory. Different types of dysregulation of cortical cholinergic transmission have been hypothesized to mediate the diverse attentional impairments that are characteristic of major neuropsychiatric disorders and that contribute to the manifestation of the main cognitive symptoms of these disorders (12–16).

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Authors and Affiliations

  1. Department of Psychology, University of Michigan, Ann Arbor, MI

    Martin Sarter

  2. Department of Psychology, Ohio State University, Columbus, OH

    John P. Bruno

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  1. Martin Sarter
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Editors and Affiliations

  1. Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  3. Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

    Ronald G. Wiley MD, PhD

  4. Advanced Targeting Systems, San Diego, CA

    Douglas A. Lappi PhD (President and Chief Scientific Officer) (President and Chief Scientific Officer)

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Sarter, M., Bruno, J.P. (2005). 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System. In: Wiley, R.G., Lappi, D.A. (eds) Molecular Neurosurgery With Targeted Toxins. Humana Press. https://doi.org/10.1007/978-1-59259-896-0_5

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