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Regulated Membrane Trafficking and Proteolysis of GPCRs

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The G Protein-Coupled Receptors Handbook

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Multiple mechanisms contribute to the physiological regulation of G protein-coupled receptors (GPCRs) present in the plasma membrane, the main site where ligand-induced signaling events are initiated. Early studies delineated the existence of distinct functional processes of receptor regulation in natively expressing cells and tissues (1,2). More recent studies have led to an explosion of new information regarding cellular and molecular mechanisms of receptor regulation.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University of California at San Francisco, San Francisco, CA

    James N. Hislop & Mark von Zastrow MD, PhD

  2. Department Pharmacology, University of California at San Francisco, San Francisco, CA

    James N. Hislop & Mark von Zastrow MD, PhD

Authors
  1. James N. Hislop
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  2. Mark von Zastrow MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY

    Lakshmi A. Devi PhD

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© 2005 Humana Press Inc., Totowa, NJ

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Hislop, J.N., von Zastrow, M. (2005). Regulated Membrane Trafficking and Proteolysis of GPCRs. In: Devi, L.A. (eds) The G Protein-Coupled Receptors Handbook. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-919-6_4

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