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Molecular Diagnostics in Hepatitis B

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Principles of Molecular Medicine

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Abstract

An estimated 400 million people are chronically infected with hepatitis B virus (HBV) and many will suffer serious liver disease as a consequence. HBV is an enveloped, partially double-stranded DNA virus, which replicates via reverse transcription of an RNA intermediate. The error rate of the reverse transcriptase generates a heterogeneous population of variants, endowing HBV with the ability to evade immune or antiviral selection pressure. Whereas HBV infection can be diagnosed by serological assays, the introduction of new antiviral agents to treat chronic infection requires monitoring by sensitive DNA amplification assays designed for quantification of HBV DNA in serum and liver tissue.

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Author information

Authors and Affiliations

  1. Victorian Infectious Diseases Reference Laboratory (VIDRL), North Melbourne and Department of Microbiology, Monash University, Clayton, Victoria, Australia

    Scott Bowden & Stephen Locarnini

Authors
  1. Scott Bowden
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  2. Stephen Locarnini
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Editor information

Editors and Affiliations

  1. Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill, NC

    Marschall S. Runge MD, PhD  & Cam Patterson MD  & 

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© 2006 Humana Press Inc.

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Bowden, S., Locarnini, S. (2006). Molecular Diagnostics in Hepatitis B. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_53

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_53

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-202-5

  • Online ISBN: 978-1-59259-963-9

  • eBook Packages: MedicineMedicine (R0)

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