Abstract
The purpose of this chapter is to summarize the main features of various signal transduction pathways utilized by the G protein-coupled 5-hydroxytryptamine (5-HT) receptors. Herein, we discuss major and secondary signals emanating from the major subtypes of 5-HT receptors (5-HT1, 5-HT2,5-HT4,5-HT5,5-HT6, and 5-HT7), as well as unique aspects of signaling for some of the subtypes. The 5-HT3 receptors, which are 5-HT gated ion channels, will not be discussed in this chapter. This chapter highlights the complexity of signaling from the diverse G protein-coupled 5-HT receptors and underscores the fundamental importance of understanding the nuances of the determinants of signaling specificity for these receptors.
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Turner, J.H., Gelasco, A.K., Ayiku, H.B., Coaxum, S.D., Arthur, J.M., Garnovskaya, M.N. (2006). 5-HT Receptor Signal Transduction Pathways. In: Roth, B.L. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-080-5_5
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DOI: https://doi.org/10.1007/978-1-59745-080-5_5
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