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Recent Results in Retinal Transplantation Give Hope for Restoring Vision

  • Chapter
Retinal Degenerations

Part of the book series: Ophthalmology Research ((OPHRES))

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Abstract

Transplanting sheets of fetal retinal pigment epithelium (RPE) together with its neuronal retina offers potential as a viable technique to prevent blindness and restore vision. This chapter presents results of the first promising FDA-approved clinical trial with a limited number of patients, bringing cautious optimism to the evaluation of the results. The basic research with several rodent degeneration models shows that transplants restore visually evoked responses in the brain, in an area of the superior colliculus corresponding to the placement of the transplant in the retina. Retinal transplants can preserve vision in an optokinetic acuity test. The mechanism of functional restoration is still unclear, but research results indicate that likely both synaptic connectivity between transplant and host and rescue of host photoreceptors are involved. The conclusion can be drawn that cotransplants of RPE together with retinal sheets have a beneficial functional effect in several animal retinal degeneration models as well as in patients in the recent clinical trial.

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Authors and Affiliations

  1. Department of Anatomical Sciences and Neurobiology, University of Louisville, Ocular Transplantation LLC, Louisville, KY

    Robert B. Aramant PhD

  2. Retina Vitreous Resource Center, Norton Audubon Hospital, Department of Ophthalmology, University of Louisville, Louisville, KY

    Norman D. Radtke MD

  3. Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA

    Magdalene J. Seiler PhD

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  1. Robert B. Aramant PhD
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  2. Norman D. Radtke MD
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  3. Magdalene J. Seiler PhD
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Editors and Affiliations

  1. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT

    Joyce Tombran-Tink PhD  & Colin J. Barnstable DPhil  & 

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Aramant, R.B., Radtke, N.D., Seiler, M.J. (2007). Recent Results in Retinal Transplantation Give Hope for Restoring Vision. In: Tombran-Tink, J., Barnstable, C.J. (eds) Retinal Degenerations. Ophthalmology Research. Humana Press. https://doi.org/10.1007/978-1-59745-186-4_19

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  • DOI: https://doi.org/10.1007/978-1-59745-186-4_19

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