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Hyperthermic Intrapleural Chemotherapy in Pleural Malignancy

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Regional Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Hyperthermic intrapleural chemotherapy for malignant pleural disease aims to increase the exposure of malignant cells at the pleural surface to chemotherapeutic agents. Evidence is presented that indeed intrapleural perfusion can result in local exposure for cisplatin and doxorubicin of 60 to 100 times the systemic exposure. Combining chemotherapeutic perfusion of the pleural cavity with mild hyperthermia of 40°–42°C can probably further increase effective tumor cell kill. Effective penetration of the drugs is limited, however. This type of therapy can therefore only work in cases of microscopic residual disease, after complete surgical resection of all malignant pleural disease. A review is presented of studies using this approach in malignant pleural mesothelioma and in pleural involvement in non-small cell lung cancer. In neither disease is there any solid evidence to prove effectivness of hyperthermic pleural chemotherapy. Only in patients with pleural metastases of malignant tymoma has this approach resulted in some unexpected long-term survivors.

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Author information

Authors and Affiliations

  1. Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Frans A. N. Zoetmulder MD, PhD

  2. Department of Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands

    Serge van Ruth MD, PhD

Authors
  1. Frans A. N. Zoetmulder MD, PhD
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  2. Serge van Ruth MD, PhD
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Editor information

Editors and Affiliations

  1. Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

  2. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) & Ulrike Stein PhD (Assistant Professor) (Professor and Head of Surgical Oncology) &  (Assistant Professor)

  3. Tumor Metastasis and Therapy Response Program, Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Ulrike Stein PhD (Assistant Professor) (Assistant Professor)

  4. Erasmus University MC—Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    Alexander M. M. Eggermont MD, PhD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

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© 2007 Humana Press Inc., Totowa, NJ

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Zoetmulder, F.A.N., van Ruth, S. (2007). Hyperthermic Intrapleural Chemotherapy in Pleural Malignancy. In: Schlag, P.M., Stein, U., Eggermont, A.M.M. (eds) Regional Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-225-0_24

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  • DOI: https://doi.org/10.1007/978-1-59745-225-0_24

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-672-6

  • Online ISBN: 978-1-59745-225-0

  • eBook Packages: MedicineMedicine (R0)

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